SF3B1
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Official Full Name
splicing factor 3b, subunit 1, 155kDa -
Overview
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
SF3B1;splicing factor 3b, subunit 1, 155kDa;MDS;PRP10;Hsh155;PRPF10;SAP155;SF3b155;splicing factor 3B subunit 1;SAP 155;pre-mRNA processing 10;spliceosome-associated protein 155;pre-mRNA splicing factor SF3b, 155 kDa subunit
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| SF3B1-4168R | Recombinant Rhesus monkey SF3B1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SF3B1-1118H | Recombinant Human SF3B1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SF3B1-1225H | Recombinant Human SF3B1 protein, GST-tagged | E.coli | Human | GST | 1-126 aa |
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| SF3B1-1708H | Recombinant Human SF3B1 protein, His-tagged | E.coli | Human | His | Leu1038~Leu1304 |
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| SF3B1-3985R | Recombinant Rhesus Macaque SF3B1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SF3B1-3985R-B | Recombinant Rhesus Macaque SF3B1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SF3B1 involved in several pathways and played different roles in them. We selected most pathways SF3B1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SF3B1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B1 itself. We selected most functions SF3B1 had, and list some proteins which have the same functions with SF3B1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
SF3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B1.
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