SF3A1
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Official Full Name
splicing factor 3a, subunit 1, 120kDa -
Overview
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
SF3A1;splicing factor 3a, subunit 1, 120kDa;splicing factor 3a, subunit 1, 120kD;splicing factor 3A subunit 1;Prp21;PRPF21;SAP114;SF3a120;Pre mRNA processing 21;Pre mRNA splicing factor SF3a;Spliceosome associated protein 114;Splicing factor 3 subunit 1;Splicing factor 3a subunit 1 120kDa;SAP 114;pre-mRNA processing 21;spliceosome-associated protein 114;pre-mRNA splicing factor SF3a (120 kDa subunit)
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SF3A1 involved in several pathways and played different roles in them. We selected most pathways SF3A1 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Splicing | PTBP1,YBX1,DNAJC8,SNRNP35,PCBP2,HNRNPA0,ZMAT5,PTBP1A,HNRNPR,SF3A3 |
| mRNA processing | NONO,OASL2,HNRNPAB,HNRNPD,HNRNPH2,ZFP346,HNRNPL,ZFP740,ZFP622,SPOP |
| mRNA Splicing - Major Pathway | HNRNPD,HNRNPL2,SF3B2,HNRNPH2,HNRNPF,SUGP1,TXNL4A,PCBP2,HNRNPA0B,HNRNPL |
| Processing of Capped Intron-Containing Pre-mRNA | TTC6,HNRNPL2,PTBP1B,HNRNPR,HNRPL,HNRNPA0B,HNRNPL,PTBP1A,PAPOLA,CCAR1 |
| Spliceosome | PRPF8,LSM8,BAT1,HNRNPA3,HSPA8,ZMAT2,TRA2A,SNRPE,DDX5,SNRNP200 |
| Gene Expression | ZNF223,ESR2A,SAP30L,PEAK1,CSTF3,ZFP36L1A,NRBP1,ZNF454,SNAPC1A,SUPT4H1 |
Protein Function
SF3A1 has several biochemical functions, for example, RNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3A1 itself. We selected most functions SF3A1 had, and list some proteins which have the same functions with SF3A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPL24,FXR2,PCBP3,CTIF,NOM1,CPSF5,RBMX,NSUN5B,TROVE2,SNRPE |
| protein binding | LIMD1,TAF7,SYT4,GJB6,CP110,CAMK2B,SPANXD,LPA,RPP30,STAT5A |
| poly(A) RNA binding | PNN,AGO2,RPS4Y2,SNRPA,PSMD4,RSL24D1,TUFM,WIBG,FAM98A,RBM8A |
Interacting Protein
SF3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3A1.
SF1;SF3A2;MAP1LC3C;PRPF40A;SP1;RBM10
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References
- Sharma, S; Wongpalee, SP; et al. Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly. GENES & DEVELOPMENT 28:2518-2531(2014).
- Wong, JJL; Lau, KA; et al. Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. CANCER SCIENCE 105:1457-1463(2014).
