SDC4
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Official Full Name
syndecan 4 -
Overview
Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules. -
Synonyms
SDC4;SYND4;syndecan 4;Syndecan 4;amphiglycan;ryudocan amphiglycan;ryudocan core protein;syndecan proteoglycan 4;syndecan 4 (amphiglycan, ryudocan)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Rhesus macaque
- Zebrafish
- Mus musculus
- Mammalian cells
- HEK293
- Mammalian Cell
- E.coli
- Human Cell
- E.coli expression system
- His
- Fc
- Non
- His&T7
- GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
SDC4 involved in several pathways and played different roles in them. We selected most pathways SDC4 participated on our site, such as ECM-receptor interaction,Cell adhesion molecules (CAMs),Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | SDC2,CD28,H2-Q10,ITGA4,CLDN5,HLA-DMA,CLDN15LB,CD6,NRXN1,HLA-DRB4 |
| Proteoglycans in cancer | PPP1CC,VAV2,SDC2,WNT9B,RHOA,NUDT16L1,ACTB,RRAS2,ELK1,WNT8A |
| ECM-receptor interaction | Npnt,VTNA,COL2A1B,COL11A1A,GP6,ITGB4,ITGB3B,COL4A5,VTNB,THBS3 |
Protein Function
SDC4 has several biochemical functions, for example, fibronectin binding,protein binding,protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC4 itself. We selected most functions SDC4 had, and list some proteins which have the same functions with SDC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C5orf20,COL4A3,CCNA2,CCNY,AGXT2L2,SH2B2,PRPF31,KCNK16,CCDC86,MYH11 |
| fibronectin binding | PLEKHA2,IGFBP5,MMP13,SFRP2,CTSS,CTSL1,LACRT,FSTL3,THBS1,FBLN1 |
| protein kinase C binding | AKT1,PARD3,HAND2,PRKCB,DACT2,TRPV4,IRS1,SQSTM1,PICK1,AVPR1B |
| thrombospondin receptor activity | CD47,F2 |
Interacting Protein
SDC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC4.
SGTA;PRKCA;GIPC1;PECAM1;TGFB3;TANK;DBN1;Lima1
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Reviews
I hope you are doing well. Yes, the protein worked well for my project thank you very much. I appreciate your help in helping me procure it. I will definitely reach out if I need any other products.
The protein worked well for my project thank you very much. I appreciate your help in helping me procure it. I will definitely reach out if I need any other products.
