SAT1
-
Official Full Name
spermidine/spermine N1-acetyltransferase 1 -
Overview
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene. -
Synonyms
SAT1;spermidine/spermine N1-acetyltransferase 1;diamine acetyltransferase 1;DC21;EC 2.3.1.57;KFSD;Polyamine N acetyltransferase 1;Polyamine N-acetyltransferase 1;Putrescine acetyltransferase;SAT;SAT1_HUMAN;Spermidine/spermine N(1) acetyltransferase 1;Spermidine/spermine N(1)-acetyltransferase 1;SSAT 1;SSAT;SSAT-1
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SAT1 involved in several pathways and played different roles in them. We selected most pathways SAT1 participated on our site, such as Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | Atp5k,ST6GALNAC5,AMY2A,PDXP,POLD4,FH1,AADAT,SMPD2,POLR2GL,AKR1B1 |
| Arginine and proline metabolism | CKM,ARG2,NOS2A,ALDH2.2,DAO1,GOT2B,SAT1A.1,ALDH4A1,CARNS1,CKMT1A |
Protein Function
SAT1 has several biochemical functions, for example, diamine N-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAT1 itself. We selected most functions SAT1 had, and list some proteins which have the same functions with SAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diamine N-acetyltransferase activity | SAT1B,SAT2,SAT1A.2,SAT1A.1 |
Interacting Protein
SAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAT1.
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References
- Ehizibolo, DO; Perez, AM; et al. Epidemiological Analysis, Serological Prevalence and Genotypic Analysis of Foot-and-Mouth Disease in Nigeria 2008-2009. TRANSBOUNDARY AND EMERGING DISEASES 61:500-510(2014).
- Tekleghiorghis, T; Moormann, RJM; et al. Serological Evidence Indicates that Foot-and-Mouth Disease Virus Serotype O, C and SAT1 are most Dominant in Eritrea. TRANSBOUNDARY AND EMERGING DISEASES 61:E83-E88(2014).
