SAP130

  • Official Full Name

    Sin3A-associated protein, 130kDa

  • Overview

    SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex;(Fleischer et al., 2003 (PubMed 12724404)).

  • Synonyms

    SAP130;Sin3A-associated protein, 130kDa;sin3A associated protein, 130kDa;histone deacetylase complex subunit SAP130;FLJ12761;mSin3A-associated protein 130;Sin3-associated polypeptide p130;130 kDa Sin3-associated polypeptide

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cell
  • HEK293
  • Yeast
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SAP130-2508H Recombinant Human SAP130, His-tagged E.coli Human His C-term-340aa
SAP130-14666M Recombinant Mouse SAP130 Protein Mammalian Cell Mouse His
Sap130-23M Recombinant Mouse Sap130 Protein, His-tagged E.coli Mouse His 35-210 a.a.
SAP130-2509H Recombinant Human SAP130 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
SAP130-2957C Recombinant Chicken SAP130 Mammalian Cell Chicken His
SAP130-1888M Recombinant Mouse SAP130 Protein (845-1057 aa), His-tagged E.coli Mouse His 845-1057 aa
SAP130-1948M Recombinant Mouse SAP130 Protein (845-1057 aa), His-tagged Yeast Mouse His 845-1057 aa
SAP130-7897M Recombinant Mouse SAP130 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SAP130-7897M-B Recombinant Mouse SAP130 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SAP130 involved in several pathways and played different roles in them. We selected most pathways SAP130 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP130 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin organization SUZ12B,SMARCC1B,MBD3B,MBD3A,SMYD2,USP22,KDM3A,SMYD3,PHF8,VPS72
    Epigenetic regulation of gene expression EED,TET3,TAF1B,SUDS3,MTF2,AEBP2,SAP30,CD3EAP,BAZ2A,SMARCA5
    Negative epigenetic regulation of rRNA expression RRP8,TAF1C,SAP30BP,SAP30L,CD3EAP,BAZ2A,SUDS3,TAF1D,TAF1B,DNMT1
    HATs acetylate histones DMAP1,C17orf81,CCDC101,ING5B,TADA3,KIAA1267,MSL2A,KAT7A,ENY2,MSL1A
    Chromatin modifying enzymes MSL1,HIST2H3C,CSRP2BP,SMYD2,ATXN7,KAT7B,KDM3B,ING5B,PHF8,RBBP4
    Gene Expression NR1H3,NR2F6B,SSRP1,SNAPC3,TBX5A,CCNT2A,PLD6,GTF3C4,LCMT2,POP7
    NoRC negatively regulates rRNA expression SAP30L,SUDS3,TAF1D,TAF1A,TAF1B,DNMT1,SIN3B,DNMT3B,CD3EAP,TAF1C

    Protein Function

    SAP130 has several biochemical functions, for example, contributes_to histone acetyltransferase activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP130 itself. We selected most functions SAP130 had, and list some proteins which have the same functions with SAP130. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to histone acetyltransferase activity EPC1,ING3,TADA2A,TEX30,KAT5,TADA3,TADA2B,SUPT3H,KAT2A,SUPT7L
    transcription coactivator activity CEBPA,USP16,UTF1,YAP1,MED6,PDLIM1,MED20,TFDP1A,NEUROD1,CARM1

    Interacting Protein

    SAP130 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP130 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP130.

    SMAD3;Max;mdm2_human_probe;SIN3B;KIF20A;HDAC1;Sap25;Tet1;HDAC2;TPX2

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