RUNX3
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Official Full Name
runt-related transcription factor 3 -
Overview
This protein is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. -
Synonyms
RUNX3;runt-related transcription factor 3;CBFA3;AML2;PEBP2A3;CBF-alpha-3;PEA2 alpha C;PEA2-alpha C;PEBP2 alpha C;PEBP2-alpha C;oncogene AML-2;transcription factor AML2;acute myeloid leukemia gene 2;acute myeloid leukemia 2 protein;core-binding factor subunit alpha-3;SL3-3 enhancer factor 1 alpha C subunit;SL3/AKV core-binding factor alpha C subunit;core-binding factor, runt domain, alpha subunit 3;polyomavirus enhancer-binding protein 2 alpha C subunit;PEBP2aC;FLJ34510;MGC16070
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RUNX3-2500H |
Active Recombinant Human Runt-related Transcription Factor 3, His-tagged
|
Yeast | Human | His |
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| RUNX3-31339TH | Recombinant Human RUNX3, His-tagged | E.coli | Human | His | 134 amino acids |
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| Runx3-8208M | Recombinant Mouse Runx3 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Asp250 |
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| RUNX3-9144Z | Recombinant Zebrafish RUNX3 | Mammalian Cell | Zebrafish | His |
|
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| RUNX3-2106HCL | Recombinant Human RUNX3 293 Cell Lysate | HEK293 | Human | Non |
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| RUNX3-3456H | Recombinant Human RUNX3 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-415aa |
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Involved Pathway
RUNX3 involved in several pathways and played different roles in them. We selected most pathways RUNX3 participated on our site, such as Endochondral Ossification,SIDS Susceptibility Pathways,TGF Beta Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | KCNH2,CDCA7L,TPH2,DLX2,TSPYL1,PHOX2A,TPPP,YBX1,SCN3B,KCNQ1 |
| TGF Beta Signaling Pathway | NOG,LEFTY1,TGFBR3,ENG,FST,FOXH1,ZNF423,ZFP423 |
| Endochondral Ossification | FRZB,COL10A1,SOX9A,ADAMTS4,RUNX2A,COL2A1,SERPINH1,PTH,NKX3.2,COL10A1A |
Protein Function
RUNX3 has several biochemical functions, for example, ATP binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX3 itself. We selected most functions RUNX3 had, and list some proteins which have the same functions with RUNX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BUC,LNX2B,ZNF155,SMAD2,FAM129A,ZBED1,CKM,FAM124A,DCUN1D1,TFB1M |
| ATP binding | UPF1,MAPKAPK2A,PLK2B,CKBB,MAP2K7,SRPK3,KIF2B,CKB,MYH9,PIK3C2B |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXH1,GATA6,SPI1B,TWIST1,FEV,SOX9A,SIM1B,NPAS4,ZNF202,MEF2C |
| transcription factor activity, sequence-specific DNA binding | NR2F6A,SOX7,TEF,ZNF454,NFE2L3,ZNF155,MYCL1,HOXB4,ARNTL1B,BLF |
| RNA polymerase II regulatory region sequence-specific DNA binding | JARID2,ATF4B2,TFAP2D,SOX13,FOXD3,DMRT1,ZBTB4,HMX3,PHF21A,RARG |
Interacting Protein
RUNX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX3.
CTNNB1;TCF7L2
RUNX3 Related Signal Pathway
Resources
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References
- Takizawa, F; Araki, K; et al. Transcription analysis of two Eomesodermin genes in lymphocyte subsets of two teleost species. FISH & SHELLFISH IMMUNOLOGY 36:215-222(2014).
- Garrity-Park, M; Loftus, EV; et al. Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: Association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation. INFLAMMATORY BOWEL DISEASES 18:275-283(2012).
