RUNX1
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Official Full Name
runt-related transcription factor 1 -
Overview
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
RUNX1;runt-related transcription factor 1;AML1;CBFA2;EVI-1;AMLCR1;PEBP2aB;AML1-EVI-1;CBF-alpha-2;PEA2-alpha B;PEBP2-alpha B;oncogene AML-1;AML1-EVI-1 fusion protein;acute myeloid leukemia 1 protein;SL3-3 enhancer factor 1 alpha B subunit;SL3/AKV core-binding factor alpha B subunit;core-binding factor, runt domain, alpha subunit 2;polyomavirus enhancer-binding protein 2 alpha B subunit
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- Insect Cell
- HEK293T
- GST
- Arg
- His
- Non
- His&T7
- Flag
- His&Fc&Avi
- His&Myc
- His&SUMO
- Myc&DDK
Involved Pathway
RUNX1 involved in several pathways and played different roles in them. We selected most pathways RUNX1 participated on our site, such as Pathways in cancer,Transcriptional misregulation in cancer,Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | FGF10,MSH2,RAF1,RET,EPAS1,FAS,PLCB2,PIK3R3,PIK3CA,RELA |
| Chronic myeloid leukemia | GAB2,TGFB3,PIK3R3,ARAF,STAT5B,TRP53,PIK3CD,AKT2,SMAD4,SHC1 |
| Acute myeloid leukemia | EIF4EBP1,PIK3CB,SFPI1,HRAS,PIK3R1,IKBKB,RPS6KB1,PPARD,AKT3,PIK3R2 |
| Transcriptional misregulation in cancer | TP53,HMGA2,SMAD1,CD14,PRCC,SFPI1,FOXO1,CDK14,RXRG,PROM1 |
Protein Function
RUNX1 has several biochemical functions, for example, DNA binding,transcription coactivator activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX1 itself. We selected most functions RUNX1 had, and list some proteins which have the same functions with RUNX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | PIAS1,RNF14,SNW1,WWTR1,MED17,AIP,SUB1B,RB1,MED21,PSMC3 |
| zinc ion binding | ANPEPA,ZDHHC21,RABIF,BRPF1,SETMAR,SNRPC,LDB3,SETDB2,LIMS3,TRIM22 |
| DNA binding | ASCL3,NUP153,SETDB1,TRNP1,POU3F2A,RAD54B,RAD51AP1,TSHZ3,HOXB13A,SP4 |
| transcription factor activity, sequence-specific DNA binding | PPARAB,HOXB6A,IRF9,SALL3,ZSCAN4D,DLX3,ESRRGA,ENO1,ZHX2,MYBL2 |
Interacting Protein
RUNX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX1.
CDK6;HIPK2;NCOR2;CBFB;ELF2;WWTR1;TAL1
RUNX1 Related Signal Pathway
Resources
Research Area
Tumor SuppressorsHemangioblast Markers
Cancer Stem Cell Transcription Factors
Epithelial Stem Cell Transcription Factors
Hemangioblast Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Neural Stem Cell Markers
Natural Killer T (NKT) Cells
Mesodermal Lineage Markers
Related Services
Related Products
References
- Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).
- Ren, TL; Han, ZJ; et al. Association of SLC22A4 Gene Polymorphism with Rheumatoid Arthritis in the Chinese Population. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 28:206-210(2014).
