RRM2
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Official Full Name
ribonucleotide reductase M2 -
Overview
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. -
Synonyms
RRM2;ribonucleotide reductase M2;ribonucleotide reductase M2 polypeptide;ribonucleoside-diphosphate reductase subunit M2;ribonucleotide reductase small chain;ribonucleotide reductase small subunit;R2;RR2;RR2M
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Zebrafish
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293
- HEK293T
- GST
- His
- T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
RRM2 involved in several pathways and played different roles in them. We selected most pathways RRM2 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | BST1,GCLM,ADH2-2,DHRS3B,POLR3A,PIP5K1AA,NANSA,ADH2-1,IDUA,GALNT1 |
| Glutathione metabolism | MGST3,RRM2B,SRM,GSTO2,GSTM6,GSTM7,GSTM,MGST1,GSTA1,GPX5 |
| p signaling pathway | PTEN,SIAH1,CD82A,SIAH1A,CASP3B,CCNB1,BAX,IGFBP3,CCNE2,TRP53 |
| Purine metabolism | PDE4C,POLR2I,GUK1A,DGUOK,NT5M,ADKA,ENPP3,AK1,ENTPD5,POLR2J2 |
| Pyrimidine metabolism | POLE3,POLR2F,UCK2A,TWISTNB,DPYS,POLR3D,TYMS,CMPK2,NT5C2B,CDA |
Protein Function
RRM2 has several biochemical functions, for example, metal ion binding,protein binding,ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM2 itself. We selected most functions RRM2 had, and list some proteins which have the same functions with RRM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SNX4,CREB3L3,HYPM,SPANXD,PIP5K1C,NFASC,TUT1,MELK,BCL7B,NACC2 |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | RRM2B,RRM1 |
| metal ion binding | GALNT4,ADAM1B,PVALB8,ZFP410,ZFP184,PKM,ZFYVE26,CYP2K16,PXDN,MB |
Interacting Protein
RRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM2.
CCNF;RRM1;FZR1;CDK1;q81kf8_bacan;TSG101
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References
- Shodai, A; Ido, A; et al. Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLOS ONE 7:-(2012).
- Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
