RRAD
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Official Full Name
Ras-related associated with diabetes -
Overview
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. -
Synonyms
RRAD;Ras-related associated with diabetes;RAD;RAD1;REM3;GTP-binding protein RAD;ras associated with diabetes;RAS (RAD and GEM) like GTP binding 3
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Mammalian cells
- HEK293T
- HEK293
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RRAD-2818H | Recombinant Human RRAD protein, His-tagged | E.coli | Human | His | 39 - 141 aa | |
| RRAD-10186Z | Recombinant Zebrafish RRAD | Mammalian Cell | Zebrafish | His |
|
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| RRAD-30772TH | Recombinant Human RRAD | Wheat Germ | Human | Non | 110 amino acids |
|
| RRAD-4985C | Recombinant Chicken RRAD | Mammalian Cell | Chicken | His |
|
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| RRAD-1676HFL | Recombinant Full Length Human RRAD Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| RRAD-1679H | Recombinant Human RRAD Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| RRAD-1918H | Recombinant Human RRAD Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RRAD-1918H-B | Recombinant Human RRAD Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Rrad-5618M | Recombinant Mouse Rrad Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RRAD-6686H | Recombinant Human RRAD Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
Involved Pathway
RRAD involved in several pathways and played different roles in them. We selected most pathways RRAD participated on our site, such as Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | STXBP3,GSK3AB,STXBP1A,STXBP2,EHD1,FLOT1,MAP3K2,MINK1,MAP4K1,STXBP4 |
Protein Function
RRAD has several biochemical functions, for example, GTP binding,GTPase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRAD itself. We selected most functions RRAD had, and list some proteins which have the same functions with RRAD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EDAR,MYBPC1,C8orf74,MAPK11,MED27,CAMLG,HIST1H4E,USF2,SAP30,SCAF8 |
| calmodulin binding | RGS2,ITPKA,AEBP1,MYO5B,INVS,ATPIF1,CNN1,MYLK,MYH13,RGS4 |
| GTPase activity | DNM3,MXA,GNA13,RAB1,CDC42,GNAQ,RRAS2,MX1,TUBA3C,RAB28 |
| GTP binding | RERGL,RASL12,GTPBP1,RND1,RRAGC,OPA1,RHOJ,ADSSL1,GIMAP5,GNA15.4 |
Interacting Protein
RRAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRAD here. Most of them are supplied by our site. Hope this information will be useful for your research of RRAD.
CCNDBP1;MMP14;CCDC141
Resources
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References
- Zhang, J; Chang, L; et al. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. CARDIOVASCULAR RESEARCH 91:90-98(2011).
- Zhu, JH; Tseng, YH; et al. Interaction of the Ras-related protein associated with diabetes Rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96:14911-14918(1999).
- Garvey, WT; Maianu, L; et al. Muscle Rad expression and human metabolism - Potential role of the novel ras-related GTPase in energy expenditure and body composition. DIABETES 46:444-450(1997).
