RPA1
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Official Full Name
replication protein A1, 70kDa -
Overview
RPA70 (HSSB, REPA1, RF-A, RP-A, p70) is a component of a heterotrimeric complex, composed of 70, 32/30 and 14 kDa subunits, collectively known as RPA. RPA is a single stranded DNA binding protein, whose DNA binding activity is believed to reside entirely -
Synonyms
RPA1;replication protein A1, 70kDa;replication protein A1 (70kD);replication protein A 70 kDa DNA-binding subunit;HSSB;REPA1;RF A;RP A;RPA70;MSTP075;RP-A p70;RF-A protein 1;replication factor A protein 1;single-stranded DNA-binding protein;R
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- His&GST
- His&SUMO
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RPA1-2366H | Recombinant Human RPA1, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| RPA1-31147H | Recombinant Human RPA1 protein, GST-tagged | E.coli | Human | GST | 317-616 aa | |
| RPA1-10194Z | Recombinant Zebrafish RPA1 | Mammalian Cell | Zebrafish | His |
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| RPA1-1369C | Recombinant Chicken RPA1 | Mammalian Cell | Chicken | His |
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| RPA1-31145TH | Recombinant Human RPA1, His-tagged | E.coli | Human | His | 257-616 a.a. |
|
| RPA1-31146H | Recombinant Human RPA1, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RPA1-2243HCL | Recombinant Human RPA1 293 Cell Lysate | HEK293 | Human | Non |
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| RPA1-1909H | Recombinant Human RPA1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RPA1-1909H-B | Recombinant Human RPA1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Rpa1-2029R | Recombinant Rat Rpa1 Protein, His-tagged | E.coli | Rat | His | Ser486-Ile680 |
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| RPA1-2030H | Recombinant Human RPA1 Protein, His&GST-tagged | E.coli | Human | His&GST | Asp18-Pro403 |
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| RPA1-3439H | Recombinant Human RPA1 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 2-616aa |
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| RPA1-3848H | Recombinant Human RPA1 protein, His-tagged | E.coli | Human | His | 1-317 aa |
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| RPA1-3849H | Recombinant Human RPA1 protein, His-tagged | E.coli | Human | His | 317-616 aa |
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| Rpa1-5578M | Recombinant Mouse Rpa1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RPA1-685HFL | Recombinant Full Length Human RPA1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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Involved Pathway
RPA1 involved in several pathways and played different roles in them. We selected most pathways RPA1 participated on our site, such as DNA replication,Nucleotide excision repair,Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | INO80E,ERCC5,MCRS1,COPS5,RFC4,RFC5,PCNA,ZFP830,COPS3,RAD23A |
| Mismatch repair | RPA2,RFC1,MLH1,MLH3,POLD4,RPA3,RFC2,RFC5,LIG1,RFC3 |
| Fanconi Anemia Pathway | MUS81,ATRIP,FANCL,HER9,FANCF,ZBTB32,MLH1,TELO2,SLX4,USP1 |
| Homologous recombination | RAD51B,RPA3,POLD4,RPA2,EME1,FUZ,RAD54L,BLM,RAD52,SHFM1 |
| DNA Replication | MCM7,POLA1,GINS4,MCM4,MCM10,RPA3,GMNN,RPA2,GINS3,MCM5 |
Protein Function
RPA1 has several biochemical functions, for example, G-protein coupled receptor activity,photoreceptor activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPA1 itself. We selected most functions RPA1 had, and list some proteins which have the same functions with RPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | VPREB1,KLRK1,IL10RB,TRAM1,NCR3,VMN1R50,AMHR2,VMN1R48,CRLF1,GRIN1B |
| photoreceptor activity | OPN1SW2,OPN1LW1,OPN4A,TMTOPS2B,OPN1MW,PARAPINOPSINB,OPN5,OPN1MW3,GRK7A,OPN1MW2 |
| G-protein coupled receptor activity | TAS2R136,OPN4.1,OLFR998,MRGPRA8,OR13A1,ADRB2B,OLFR50,TAS2R116,TAS2R108,TAAR9 |
Interacting Protein
RPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPA1.
RPA2;RPA3;WRN
Resources
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References
- Takaya, J; Kusunoki, S; et al. Protein interaction and cellular localization of human CDC45. JOURNAL OF BIOCHEMISTRY 153:381-388(2013).
- Shen, GP; Pan, QH; et al. Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese. INTERNATIONAL JOURNAL OF CANCER 129:1459-1466(2011).
