ROS1
-
Official Full Name
c-ros oncogene 1 , receptor tyrosine kinase -
Overview
The c-ros proto-oncogene encodes a receptor tyrosine kinase similar to insulin receptor proteins and expressed in specific epithelial cells (1). During mouse development the Ros receptor plays an important role in the differentiation of epididymal epithel -
Synonyms
ROS1;c-ros oncogene 1 , receptor tyrosine kinase;v ros avian UR2 sarcoma virus oncogene homolog 1 , v ros UR2 sarcoma virus oncogene homolog 1 (avian);proto-oncogene tyrosine-protein kinase ROS;c ros 1;MCF3;ROS;proto-oncogene c-Ros;proto-oncogene
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Mouse-ear cress
- Sf9 Cells
- E.coli
- Mammalian Cells
- HEK293
- GST
- His&T7
- His
- His&Fc&Avi
- His&SUMO
Involved Pathway
ROS1 involved in several pathways and played different roles in them. We selected most pathways ROS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ROS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ROS1 has several biochemical functions, for example, ATP binding,protein binding,protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROS1 itself. We selected most functions ROS1 had, and list some proteins which have the same functions with ROS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | EPHB3,DYRK1AA,RFC2,SHPRH,CHD6,GC3,VSIG8B,ULK4,ABCA1,PKDCCA |
| protein tyrosine kinase activity | ALK,PTK7,TTN,SHC1,ERBB3A,FGFR2,FGFR1A,DYRK2,LTK,PTK2BB |
| protein binding | CUL3,BCL6,DPH3,S100A8,MYH7,HIST2H3C,MYO6,HNRNPM,CRABP2,KAT7 |
| protein phosphatase binding | EGFR,STAT6,EIF2AK3,PIK3R2,JAK1,LCK,MAPK14,PPP6R3,CTNNB1,CDH2 |
| transmembrane receptor protein tyrosine kinase activity | EPHB4B,DDR1,EGFRA,EPHB4A,INSRR,EPHA4A,EPHA2,TIE1,CSF1RA,ERBB3B |
Interacting Protein
ROS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROS1.
PTPN6;PKM;PTPN1
Resources
Related Services
Related Products
References
- Zhuang, X; Herbert, JMJ; et al. Identification of novel vascular targets in lung cancer. BRITISH JOURNAL OF CANCER 112:485-494(2015).
- Chiari, R; Buttitta, F; et al. Dramatic Response to Crizotinib in ROS1 Fluorescent In Situ Hybridization- and Immunohistochemistry-Positive Lung Adenocarcinoma: A Case Series. CLINICAL LUNG CANCER 15:470-474(2014).
