ROR2
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Official Full Name
receptor tyrosine kinase-like orphan receptor 2 -
Overview
ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. They are characterized by the presence of extracellular frizzled-like cysteine-rich domains and membrane-proximal kringl -
Synonyms
ROR2;receptor tyrosine kinase-like orphan receptor 2;BDB, BDB1, NTRKR2;tyrosine-protein kinase transmembrane receptor ROR2;neurotrophic tyrosine kinase receptor-related 2;BDB;BDB1;NTRKR2;MGC163394
Recombinant Proteins
- Human
- Chicken
- Mouse
- HEK293
- Sf9 Cells
- E.coli
- Mammalian Cells
- Human Cells
- Fc
- GST
- His&GST
- His
- His&Flag
- Flag
- Myc&DDK
- His&Avi
- His&Fc&Avi
Involved Pathway
ROR2 involved in several pathways and played different roles in them. We selected most pathways ROR2 participated on our site, such as Beta-catenin independent WNT signaling,Cardiac Progenitor Differentiation,Noncanonical Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt Signaling Pathway NetPath | MTAP1B,PAX2,TFAP2A,BCL9,NR5A1,ANKRD6,HIPK2,CSNK2A1P,CRYBB2,BRD7 |
| Noncanonical Wnt signaling pathway | CHD7,CTHRC1 |
| Signaling by Wnt | USP34,TNKS,SOX4A,FAM123B,WIF1,LGR6,SRY,TLE3B,RNF43,RNF146 |
| Cardiac Progenitor Differentiation | NKX2,NOG,LIN28A,LIN28B,TBX20,SIRPA,BMP1,ZFP42,IRX4,SOX1 |
| Signal Transduction | USP4,FST,APLN,RNF43,ARHGAP4,APOA4A,PAG1,GPR4,CDH5,OPN4.1 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | ROR1 |
| Beta-catenin independent WNT signaling | ITPR2,AP2M1,AP2A2,RYK,CTNNB2,AP2S1,AGO3,AP2B1,PRICKLE1,AGO1 |
| PCP/CE pathway | PRICKLE1B,PRICKLE1,RYK,ROR1 |
Protein Function
ROR2 has several biochemical functions, for example, ATP binding,Wnt-protein binding,frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROR2 itself. We selected most functions ROR2 had, and list some proteins which have the same functions with ROR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | WNT5B,DVL3,WNT4A,FZD1,WNT8A,CTHRC1,WNT2BA,SDCBP,DVL3A,DVL1B |
| transmembrane receptor protein tyrosine kinase activity | EK1,TYRO3,ERBB3A,NTRK3,NTRK2B,FGFR1A,IGF1RA,FLT1,INSRR,PDGFRA |
| Wnt-protein binding | FZD3,FZD5,FZD6,PORCN,FZD7B,GM12824,SFRP1,GPR177,LRP5L,FZD2 |
| metal ion binding | CYP2AA2,RFK,ESR2B,ZFP330,ZIM3,MPO,NAIP1,ARID2,ZNF317,ZNF518A |
| protein binding | NOXO1,SMAD1,WASF2,ISG15,CA1,ANKRA2,STX3,NFS1,GTSE1,PLGRKT |
| ATP binding | CDK5,DHX35,KIF4A,MAP3K15,NLRP2,PAK2B,UBA1,NMRK2,HKDC1,CMPK1 |
Interacting Protein
ROR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROR2.
HSP90AB1
Resources
Research Area
Receptor Tyrosine Kinases (RTKs) in the Akt PathwayWnt Receptors
Neural Stem Cell Markers
Neural Progenitor Cell Markers
Related Services
Related Products
References
- Ishizuya-Oka, A; Kajita, M; et al. Thyroid Hormone-Regulated Wnt5a/Ror2 Signaling Is Essential for Dedifferentiation of Larval Epithelial Cells into Adult Stem Cells in the Xenopus laevis Intestine. PLOS ONE 9:-(2014).
- Bauer, M; Benard, J; et al. WNT5A Encodes Two Isoforms with Distinct Functions in Cancers. PLOS ONE 8:-(2013).
