RGMA
-
Official Full Name
repulsive guidance molecule family member A -
Overview
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. -
Synonyms
RGMA;repulsive guidance molecule family member A;BC059072;C230063O06;repulsive guidance molecule A;RGM domain family, member A
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Chicken
- Cynomolgus
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- Insect Cells
- His
- His&Avi
- Flag
- Non
- Myc&DDK
- His&Myc
- His&Fc&Avi
Involved Pathway
RGMA involved in several pathways and played different roles in them. We selected most pathways RGMA participated on our site, such as Axon guidance,BMP receptor signaling,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMP receptor signaling | AHSG,CTDSP1,CTDSPL,NOG,SOSTDC1,CALML4,GREM1,SKI,CTDSP2,RGMB |
| Spinal Cord Injury | LILRB3,RTN4R,OMG,LGALS3,TNFSF13B,GAP43,RTN4,AIF1,PTPRZ1,GDNF |
| Netrin-1 signaling | UNC5D,NTN1A,TRPC5,RNF8,SIAH2,PITPNA,EZRA,RGMB,HFE2,NTN1B |
| Developmental Biology | PAQR3A,DUSP10,DOCK1,EFNB2,KBTBD7,CLTC,KDR,BOC,EFNA3B,ARPC4 |
| Axon guidance | EGF,WDR83,DCC,EFNA3,HFE2,ROCK1,EPHA2,Unc5b,CSF2,COL6A2 |
Protein Function
RGMA has several biochemical functions, for example, coreceptor activity,glycoprotein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGMA itself. We selected most functions RGMA had, and list some proteins which have the same functions with RGMA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coreceptor activity | PVRL1,TGFBR3,CCR5,RGMB,CCR8,CD86,NRP1,CXCR7,RAMP2,CD4 |
| protein binding | HUWE1,THOP1,CYHR1,UBE2R2,EPN1,TRIM38,SERP1,TRIM16,NAA10,ATP2A1 |
| glycoprotein binding | LDLR,HSPA5,ERLEC1,FBXO6,ACE2,CNTN2,CANX,B2M,Itgam&Itgb2,SDCBP |
| transferrin receptor binding | TF,HFE,SNX2,SNX4,Trf,SNX1,HFE2,CD81 |
Interacting Protein
RGMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGMA here. Most of them are supplied by our site. Hope this information will be useful for your research of RGMA.
TERF2IP;SGSM2;PPP1R16A;BDP1;NCOR2;TCEB2;SAMD4B;NBEAL1;SPICE1;PPHLN1;ANO3;HIPK2;TXNIP;CLK4
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