RFC5
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Official Full Name
replication factor C (activator 1) 5, 36.5kDa -
Overview
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. -
Synonyms
RFC5;replication factor C (activator 1) 5, 36.5kDa;replication factor C (activator 1) 5 (36.5kD);replication factor C subunit 5;RFC36;36 kDa subunit;A1 36;A1 36 kDa subunit;A136;Activator 1 36 kDa subunit;Activator 1;Activator 1 subunit 5;Activator 136 kDa subunit;MGC1155;Replication factor C 5 isoform 1;Replication Factor C;Replication Factor C36 kDa subunit;Replication factor c5;RFC 36.5 kD subunit;RFC 5;RF-C 36 kDa subunit;RFC, 36.5 kD subunit;replication factor C, 36-kDa subunit
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFC5-3337H | Recombinant Human RFC5 protein, His-tagged | E.coli | Human | His | 219-341 aa |
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| RFC5-1149Z | Recombinant Zebrafish RFC5 | Mammalian Cell | Zebrafish | His |
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| RFC5-3859R | Recombinant Rhesus monkey RFC5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RFC5-2409HCL | Recombinant Human RFC5 293 Cell Lysate | HEK293 | Human | Non |
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| RFC5-01H | Recombinant Human RFC5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| RFC5-1699H | Recombinant Human RFC5 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Ile219 |
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| Rfc5-1700M | Recombinant Mouse Rfc5 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Thr63~Ala339 |
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| RFC5-3676R | Recombinant Rhesus Macaque RFC5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RFC5-3676R-B | Recombinant Rhesus Macaque RFC5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RFC5-6870HF | Recombinant Full Length Human RFC5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 340 amino acids |
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Involved Pathway
RFC5 involved in several pathways and played different roles in them. We selected most pathways RFC5 participated on our site, such as DNA replication,Nucleotide excision repair,Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | POLD1,rnhA,RFC2,RNASEH2A,POLE,GINS2,POLE2,PRIM2,GMNN,RPA3 |
| Nucleotide Excision Repair | GTF2H1,ERCC6,RFC2,POLE3,COPS8,XPA,GTF2H5,ZFP830,GTF2H2,YY1A |
| Mismatch repair | RFC1,RPA1,RFC4,RFC2,MSH6,POLD2,MLH3,MSH3,PCNA,RFC3 |
Protein Function
RFC5 has several biochemical functions, for example, ATP binding,contributes_to DNA clamp loader activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFC5 itself. We selected most functions RFC5 had, and list some proteins which have the same functions with RFC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | POMK,IGF1RA,PAPOLB,SMC4,ACSS3,ABCC1,CHD1,PANK2,SLFN5,ERN1 |
| enzyme binding | EHHADH,NKX2-1,ATXN10,RYR2,VAPB,DDX5,CBX4,PRKCE,SRC,APBA3 |
| protein binding | MS4A12,KIAA1530,MOB1A,DTX3L,DLX4,CPSF6,MESDC1,TEAD1,TREX1,MED30 |
| contributes_to DNA clamp loader activity | DSCC1,RFC2,RFC4 |
Interacting Protein
RFC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFC5.
RFC4;TRIM38;XIAP;NAB2
Resources
Related Services
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References
- Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
- Liu, SM; Chen, WP; et al. Distinguishing between cancer cell differentiation and resistance induced by all-trans retinoic acid using transcriptional profiles and functional pathway analysis. SCIENTIFIC REPORTS 4:-(2014).
