RFC2
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Official Full Name
replication factor C (activator 1) 2, 40kDa -
Overview
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
RFC2;replication factor C (activator 1) 2, 40kDa;replication factor C (activator 1) 2 (40kD);replication factor C subunit 2;A1;activator 1;RFC40;A1 40 kDa subunit;RF-C 40 kDa subunit;activator 1 subunit 2;replication factor C 2;activator 1 40 k
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Human
- Mouse
- Mammalian Cell
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- His
- Non
- His&T7
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
RFC2 involved in several pathways and played different roles in them. We selected most pathways RFC2 participated on our site, such as DNA replication,Nucleotide excision repair,Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | RFC5,rnhA,RFC3,PRIM2,POLE4,RNASEH2B,RPA4,POLE,GINS1,RPA3 |
| Nucleotide Excision Repair | RFC4,RPA1,LIG1,USP45,CHD1L,CUL4A,RPA2,COPS3,POLE,COPS7A |
| Mismatch repair | RPA1,MLH3,PMS2,MSH2,PCNA,MSH6,RFC1,POLD2,RFC5,LIG1 |
Protein Function
RFC2 has several biochemical functions, for example, ATP binding,contributes_to DNA clamp loader activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFC2 itself. We selected most functions RFC2 had, and list some proteins which have the same functions with RFC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to DNA clamp loader activity | RFC5,DSCC1,RFC4 |
| protein binding | LRRC4B,LRPAP1,HACE1,KIFC3,ALG13,LILRB4,DDR2,RPS6KA5,RNF4,COA3 |
| ATP binding | MCM3L,ACTA1A,ABCA1B,PFKFB2,ATP5A1,OPLAH,DGKB,UBA1,AK3,DHX58 |
Interacting Protein
RFC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFC2.
RFC4;RFC1;PRKAR1A;RFC5
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