RBL2

  • Official Full Name

    retinoblastoma-like 2 (p130)

  • Overview

    p130 is a tumor suppressor of the pocket protein family whose expression is posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation of p130 expression in proliferating cells was investigated and results indicate that the decline of p130 expression as G0 cells reenter the cell cycle is due to a decrease in protein stability. In vitro polyubiquitination of p130 by SCF(Skp2) was specifically dependent on phosphorylation of p130 on Serine 672 (1). The retinoblastoma family of proteins including pRB, p107 and p130 undergoes cell cycle dependent phosphorylation during the mid-G1 to S phase transition. This phosphorylation is dependent upon the activity of cyclin D/cdk4. In contrast to pRB and p107, p130 is phosphorylated during G0 and the early G1 phase of the cell cycle. Also it is thought that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. Data indicates complementary roles for the Rb/E2F pathway in the control of telomere length (3).

  • Synonyms

    RBL2;retinoblastoma-like 2 (p130);retinoblastoma-like protein 2;p130;Rb2;PRB2;RBR-2;retinoblastoma-related protein 2;130 kDa retinoblastoma-associated protein;FLJ26459

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • HEK293T
  • Mamanlian cells
  • GST
  • Myc&DDK
  • His
  • Non
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
RBL2-2205H Recombinant Human RBL2, GST-tagged E.coli Human GST N-term-350aa
RBL2-2483H Recombinant Human RBL2 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
RBL2-2984C Recombinant Chicken RBL2 Mammalian Cell Chicken His
RBL2-4955R Recombinant Rat RBL2 Protein Mammalian Cell Rat His
RBL2-2483HCL Recombinant Human RBL2 293 Cell Lysate HEK293 Human Non
RBL2-4358H Recombinant Human RBL2 protein, His-tagged E.coli Human His 417-616aa
RBL2-4614R Recombinant Rat RBL2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
RBL2-4614R-B Recombinant Rat RBL2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Rbl2-5409M Recombinant Mouse Rbl2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
RBL2-6051HFL Recombinant Full Length Human RBL2 protein, Flag-tagged Mamanlian cells Human Flag Full L.
RBL2-881H Recombinant Human RBL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    RBL2 involved in several pathways and played different roles in them. We selected most pathways RBL2 participated on our site, such as FoxO signaling pathway,Cell cycle,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis HIST2H2BE,TRAF1,HIST1H4F,HIST1H2BN,CASP8,SRF,RBL1,NRAS,SKP2,DLG1
    FoxO signaling pathway GADD45B,G6PC3,EP300,PLK4,ATG12,NLK1,AKT3A,PRKAG2A,CDKN2B,KRAS
    Cell cycle TBC1D8,MCM6,SETB,YWHABA,ORC1,TGFB2,HTATIP,CEP72,FAM175A,SKA2
    PIK-Akt signaling pathway FGF12,MCL1,GNG8,IFNAR2,TSC2,SGK1,PIK3CA,YWHAG,BCL2L1,FGF14

    Protein Function

    RBL2 has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBL2 itself. We selected most functions RBL2 had, and list some proteins which have the same functions with RBL2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF620,RCOR1,ZKSCAN17,TADA2A,GTF2F1,ZNF311,PARP2,PAX6,STRA13,ASH1L
    protein binding ZSCAN10,ISCU,C12orf40,SSBP3,HYAL3,ATF3,NTN4,KRTAP4-12,TEX264,RAB24

    Interacting Protein

    RBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBL2.

    CDK2;E2F4;LIN54

    Resources

    Research Area

    CKIs(Cyclin Dependent Kinase Inhibitors)

    References

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