RAPGEF4
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 4 -
Overview
EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal -
Synonyms
RAPGEF4;Rap guanine nucleotide exchange factor (GEF) 4;rap guanine nucleotide exchange factor 4;exchange protein directly activated by cAMP 2;cAMP GEFII;cAMP regulated guanine nucleotide exchange factor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAPGEF4-2182H | Recombinant Human RAPGEF4, His-tagged | E.coli | Human | His | C-term-300aa | |
| RAPGEF4-2637H | Recombinant Human Rap Guanine Nucleotide Exchange Factor (GEF) 4 | E.coli | Human | Non |
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| RAPGEF4-2520HCL | Recombinant Human RAPGEF4 293 Cell Lysate | HEK293 | Human | Non |
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| Rapgef4-5378M | Recombinant Mouse Rapgef4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
RAPGEF4 involved in several pathways and played different roles in them. We selected most pathways RAPGEF4 participated on our site, such as Adaptive Immune System,Adrenergic signaling in cardiomyocytes,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrin alphaIIb beta3 signaling | RAPGEF3,FN1B,LOC100514666,ITGB3A |
| Hemostasis | SLC16A1,G6b,MERTK,SH2B3,ANGPT2A,KCNMB1,FCER1GL,IGF2B,MFN2,KCNMB2 |
| Insulin secretion | CCKAR,ATP1B3,GCG,ITPR3,KCNMB4,ATF4,ATP1B1,ATP1B2,PLCB4,PLCB2 |
| Integration of energy metabolism | ARL2,GNG13A,ARL2BP,KCNS3A,SYT5,KCNJ11,AKAP5,GNG13B,KCNS3,KCNB1 |
| Adrenergic signaling in cardiomyocytes | PLCB2,CACNA2D2,CREB3L1,CALM2A,PIK3CG,ADRB3B,ATF2,CACNA2D4,ATP1A4,ADCY1 |
| Immune System | CD226,ISG20,CSHL1,RNF144B,ABI2,DEFA3,DCTN3,CD300C,SPSB2,SH3RF1 |
| Adaptive Immune System | AKR1C1,CD300LD,ARF1,AP2A1,SPTBN2,LILRB4,CTSD,HUWE1,KIF18A,LILRA3 |
Protein Function
RAPGEF4 has several biochemical functions, for example, Ras GTPase binding,Ras guanyl-nucleotide exchange factor activity,cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF4 itself. We selected most functions RAPGEF4 had, and list some proteins which have the same functions with RAPGEF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PML,CLCF1,MAPK4,C10orf33,USP14,BBS10,FSHR,AGPAT4,CP110,SCARA3 |
| guanyl-nucleotide exchange factor activity | P2RY12,PTGIR,RAPGEF3,VAV2,DOCK7,RINL,DOCK8,FARP2,DENND6A,RASGEF1BA |
| cAMP binding | PDE2A,PDE3A,CNGA2,PDE10A,HCN4,PRKAR1A,PRKAR2A,PDE4A,PDE4D,CNGA4 |
| Ras GTPase binding | RGL3,RASGRP3,SPHK2,MAP2K1,RIN1,SH3BP4,RAP1GAP,CIB1,RAP1A,MLLT4 |
| Ras guanyl-nucleotide exchange factor activity | RASGRP3,RASGEF1A,RAB3A,RASGRP1,RGL2,RASGEF1B,ADRB1,RASGEF1BB,KNDC1,RASGRP4 |
Interacting Protein
RAPGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF4.
C16orf45;ATXN1;SLC22A7;3',5'-cyclic amp
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References
- Hwang, JY; Sim, X; et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. DIABETES 64:291-298(2015).
- Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).
