QKI
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Official Full Name
QKI, KH domain containing, RNA binding -
Overview
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene. -
Synonyms
QKI;QKI, KH domain containing, RNA binding;quaking homolog, KH domain RNA binding (mouse);protein quaking;QK3;RNA binding protein HQK;quaking homolog, KH domain RNA binding;homolog of mouse quaking QKI (KH domain RNA binding protein);QK;Hqk;QK1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
QKI involved in several pathways and played different roles in them. We selected most pathways QKI participated on our site, such as Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with QKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diurnally regulated genes with circadian orthologs | NCKAP1,EIF4G2,TOB1,CRY1,ERC2,KLF9,AZIN1,SF3A3,MYF6,CRY2 |
Protein Function
QKI has several biochemical functions, for example, SH3 domain binding,mRNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by QKI itself. We selected most functions QKI had, and list some proteins which have the same functions with QKI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SULT4A1,ZFP36,MAP4K4,KCTD17,XAGE2,FSHB,TMEM115,SCN5A,CAB39,SERPINA3 |
| mRNA binding | RBFOX1,MECP2,RC3H2,LUC7L,RBM4,NXF2,CELF1,SNRNP70,IGF2BP2A,DCP1B |
| SH3 domain binding | ERRFI1,PTTG1,FAM125A,SGIP1,PDE4D,NCKIPSD,ABL1,SOS1,CD3E,CTTNBP2 |
| poly(A) RNA binding | EIF1B,RPL24,HSPD1,GANAB,POLDIP3,LAS1L,GNL3,RIMS2,PA2G4,RPL31 |
Interacting Protein
QKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with QKI here. Most of them are supplied by our site. Hope this information will be useful for your research of QKI.
RBPMS;FUBP3;RBFOX2;PTBP1;HNRNPK;SNRPA
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References
- Liu, QY; Luo, Y; et al. Preparation and Characterizations of Polyclonal Antibodies Against STAR Protein QKI7b. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 169:2273-2280(2013).
- Zhan, R; Yamamoto, M; et al. A DEAD-box RNA helicase Ddx54 protein in oligodendrocytes is indispensable for myelination in the central nervous system. JOURNAL OF NEUROSCIENCE RESEARCH 91:335-348(2013).
