PYGB
-
Official Full Name
phosphorylase, glycogen; brain -
Overview
Glycogen phosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogen phosphorylase. This isoform of the enzyme exists in cardiac (heart) and brain tissue.The enzyme is one of the new cardiac markers which are discussed to improve early diagnosis in acute coronary syndrome. A rapid rise in blood levels can be seen in myocardial infarction and unstable angina. -
Synonyms
Glycogen Phosphorylase Isoenzyme BB;GPBB;brain form;Brain glycogen phosphorylase;Glycogen phosphorylase;Glycogen phosphorylase B;Glycogen phosphorylase brain form;MGC9213;Phosphorylase glycogen brain;PYGB;PYGB_HUMAN;phosphorylase, glycogen;brain;glycogen phosphorylase, brain form;OTTHUMP00000030488;EC 2.4.1.1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Heart
- Mammalian cells
- HEK293
- HEK293T
- E. coli
- GST
- His
- Non
- His&T7
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PYGB involved in several pathways and played different roles in them. We selected most pathways PYGB participated on our site, such as Starch and sucrose metabolism,Metabolic pathways,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PYGMA,PIK3CD,RPS6KA3B,MAPK8B,PDPK1,PPP1R3C,PIK3CA,PYGM,PRKCB,MAPK10 |
| Metabolic pathways | LTC4S,CYP2C37,PIGF,UROS,GALNT13,EPRS,CYP4F2,GDA,ACADVL,AGPAT5 |
| Starch and sucrose metabolism | UXS1,UGDH,UGT2B15,GAA,GBA3,PGM2,GYS2,HKDC1,UGP2A,UGT1A6B |
| Insulin signaling pathway | INS1,PRKCZ,PRKACAA,HRASB,TRIP10A,FLOT1B,MAP2K1,INSB,CALM3,PTPN1 |
Protein Function
PYGB has several biochemical functions, for example, carbohydrate binding,drug binding,glycogen phosphorylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGB itself. We selected most functions PYGB had, and list some proteins which have the same functions with PYGB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | CLEC3A,VCAN,FBXO2,CD72,UAP1,ILLR4,CD209B,LGALS2,Pla2r1,LPHN1 |
| drug binding | GSTP2,MT3,SRP54,CHRNB2,ADRB2,DRD4,CHRNB4,CHRNB3,PDE2A,HMGB2 |
| glycogen phosphorylase activity | PYGM,PYGL,PYGMA,PYGMB |
| protein homodimerization activity | GSTM1,NACC2,TG,PEX11A,TOP2A,RAP1GAP,S100A5,NBL1,IL6R,TENM3 |
| pyridoxal phosphate binding | GPT2L,CBS,GAD1,HINT2,MARC2,AGXT2L2,CTHL,AADAT,CCBL2,OAT |
| protein binding | ZNF625,LCOR,NBR1,IGSF1,ARRB2,ADAM33,CD244,RNF139,CTLA2B,B3GAT3 |
Interacting Protein
PYGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGB here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGB.
PYGL;SIAH1;6319953;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ere_dna;LRRK2;Prkci;Tnpo1;Tsc1
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References
- Terashima, M; Fujita, Y; et al. KIAA1199 interacts with glycogen phosphorylase kinase beta-subunit (PHKB) to promote glycogen breakdown and cancer cell survival. ONCOTARGET 5:7040-7050(2014).
- Das, A; Durrant, D; et al. Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice POTENTIAL ROLE OF ATTENUATED OXIDATIVE STRESS AND ALTERED CONTRACTILE PROTEIN EXPRESSION. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4145-4160(2014).
