PTGES
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Official Full Name
prostaglandin E synthase -
Overview
Prostaglandin E synthase-1 (PGE synthase-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. PGE synthase-1 is a 16 kDa membrane associated protein with glutathione-dependent activity. The mRNA for PGE synthase-1 is expressed in a variety of tissues including prostate, testes, and small intestine as well as in A549 and HeLa cells. PGE synthase-1 protein expression is increased in A549 cells following treatment with IL-1β. -
Synonyms
PTGES;prostaglandin E synthase;MGST1L1;glutathione S transferase 1 like 1;MGST IV;MGST1 L1;MGST1 like 1;microsomal glutathione S transferase 1 like 1;microsomal prostaglandin E synthase 1;p53 induced gene 12;PIG12;TP53I12;tumor protein p53 ind
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- Mouse
- Macaca fascicularis
- Dog
- Bovine
- Mus musculus
- Horse
- E.coli
- Mammalian Cell
- HEK293
- Sf21 Insect Cell
- Insect Cell
- HEK293T
- In vitro E. coli expression system
- Mamanlian cells
- E.coli expression system
- His&GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
PTGES involved in several pathways and played different roles in them. We selected most pathways PTGES participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | POLR2EB,ADH2-1,FUK,UGT5G1,FUT6,IVD,DCXR,PRIM1,ALG10B,SHMT1 |
| Arachidonic acid metabolism | PTGDSA,PLA2G2D,PLB1,PLA2G3,AKR1C3,ALOX12E,FAM213B,CYP2V1,GGT1,PLA2G10 |
Protein Function
PTGES has several biochemical functions, for example, glutathione binding,prostaglandin-E synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES itself. We selected most functions PTGES had, and list some proteins which have the same functions with PTGES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione binding | GSS,MGST1,LTC4S,PTGES2,PTGESL,GSTP2,GSTM7,GPX1,GSTM2,GSTM3 |
| prostaglandin-E synthase activity | PTGES3,PTGESL,PTGES2 |
Interacting Protein
PTGES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES.
GOLT1B
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References
- Reddy, SA; Shelar, SB; et al. Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-kappa B- and MAPK-dependent manner. INTERNATIONAL IMMUNOPHARMACOLOGY 24:440-450(2015).
- Gobel, C; Breitenbuecher, F; et al. Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. CELL DEATH & DISEASE 5:-(2014).
