PTGDS
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Official Full Name
prostaglandin D2 synthase 21kDa (brain) -
Overview
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. Lipocalin-type PGDS (L-PGDS, a.k.a.β-trace) is a homodimer with each subunit ranging in size from 20-31 kDa, depending on glycosylation. L-PGDS has two functions: it catalyzes the conversion of PGH2 to PGD2 and acts as a carrier protein for lipid-like molecules (i.e., retinoids and thyroid hormones). PGD2 is involved in sleep regulation, nociception, platelet aggregation, and allergic and inflammatory responses. There is also some evidence to indicate the involvement of PGD2 and its J-series metabolites in pregnancy and parturition. -
Synonyms
PTGDS;prostaglandin D2 synthase 21kDa (brain);prostaglandin D2 synthase (21kD, brain);prostaglandin-H2 D-isomerase;L PGDS;lipocalin type prostaglandin D synthase;PGDS;cerebrin-28;PGD2 synthase;beta-trace protein;prostaglandin D synthase;prostaglandin-D2 synthase;glutathione-independent PGD synthase;glutathione-independent PGD synthetase;lipocalin-type prostaglandin D synthase;lipocalin-type prostaglandin-D synthase;PDS;PGD2;LPGDS;PGDS2;L-PGDS
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Human Cell
- Mammalian cells
- HEK293T
- His
- Non
- GST
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
PTGDS involved in several pathways and played different roles in them. We selected most pathways PTGDS participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PTGDSB,ALOX5B.2,CYP2J6,CYP4B1,FAAH2B,DPEP1,CYP2C55,CYP2B19,ALOX5B.3,ALOX12B |
| Metabolic pathways | NDUFS8A,ctaG,ZNF408,ATP5F1,AGPAT9,INPP5L,HSD3B1,UGT1A6,NADK2,SORD |
Protein Function
PTGDS has several biochemical functions, for example, fatty acid binding,prostaglandin-D synthase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDS itself. We selected most functions PTGDS had, and list some proteins which have the same functions with PTGDS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fatty acid binding | HNF4A,NDUFAB1,O3far1,FABP2,FABP5,FABP10A,Alb,FABP7B,ACOX2,APOC1 |
| transporter activity | TMEM184C,ABCA13,SLC4A11,FABP12,ASNA1,RLBP1,SLC13A5,LCN2,TMEM184BA,RASSF9 |
| protein binding | RPL37A,KCNJ5,LZTS1,BMF,FLI1,NPPA,TTPA,SCEL,RAB10,STMN1 |
| retinoid binding | RBP4L,RBP2,CRABP2,RBP1,RBP3,RBP5,CRABP1,LCN5 |
| prostaglandin-D synthase activity | HPGDS |
Interacting Protein
PTGDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDS.
KRTAP10-7;CACNA1A;BCAT2;EGFR;AKT1;MLH1;ATXN1;q5ngw2_fratt;menE;q81z98_bacan;q4r4p0_macfa;CTSB
Resources
Research Area
Neurotransmitter Associated EnzymesEicosanoids and Regulators
Inflammatory Mediators
Prostaglandin Synthases
Related Services
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References
