PSPN
-
Official Full Name
persephin -
Overview
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. -
Synonyms
PSPN;persephin;PSP
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- Non
- His
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PSPN-1003H |
Active Recombinant Human PSPN
|
E.coli | Human | Non | Ala61-Gly156 |
|
| Pspn-1010M |
Active Recombinant Mouse Pspn
|
E.coli | Mouse | Non | Ala61-Gly156 |
|
| Pspn-5209M |
Active Recombinant Mouse Pspn Protein
|
E.coli | Mouse |
|
||
| Pspn-21M | Recombinant Mouse Pspn protein | E.coli | Mouse | Non | 96 |
|
| PSPN-4793R | Recombinant Rat PSPN Protein | Mammalian Cell | Rat | His |
|
|
| PSPN-570H | Recombinant Human PSPN protein | E.coli | Human | Non | 96 |
|
| PSPN-2733HCL | Recombinant Human PSPN 293 Cell Lysate | HEK293 | Human | Non |
|
|
| PSPN-001H | Recombinant Human PSPN Protein, His tagged | E. coli | Human | His | 22-156 aa |
|
| PSPN-098H | Active Recombinant Human PSPN Protein | E.coli | Human | 61-156 a.a. |
|
|
| PSPN-231H | Active Recombinant Human PSPN Protein | E.coli | Human |
|
||
| PSPN-361H | Recombinant Human PSPN Protein, His/GST-tagged | E.coli | Human | His&GST | Val29~Gly156 |
|
| PSPN-4452R | Recombinant Rat PSPN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| PSPN-4452R-B | Recombinant Rat PSPN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| PSPN-6006H | Recombinant Human PSPN Protein (Ala61-Gly156), N-His tagged | E.coli | Human | His | Ala61-Gly156 |
|
Involved Pathway
PSPN involved in several pathways and played different roles in them. We selected most pathways PSPN participated on our site, such as Axon guidance,Developmental Biology,NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | TRPC7,NR6A1,ST8SIA2,PRDM14,EFNA3B,SPTB,PLXNC1,MYL12B,SCN9A,SCN2A |
| Axon guidance | ABLIM3,DOCK1,RAC1,PAK3,RNF8,CSF2,RASA1,SEMA5B,ITGB3A,AGRN |
| NCAM signaling for neurite out-growth | GFRA2,COL9A1A,GFRA1,COL9A1B,NRTN,ST8SIA2,GFRA4,GDNF |
| NCAM1 interactions | COL9A1A,GFRA2,GDNF,COL9A1B,GFRA1,NRTN,GFRA4 |
Protein Function
PSPN has several biochemical functions, for example, growth factor activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSPN itself. We selected most functions PSPN had, and list some proteins which have the same functions with PSPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | FGF18,RABEP2,NDR2,CTGF,MSTNB,LFT2,IGF3,FGF13B,FGF2,LEFTY2 |
| receptor binding | WNT7A,TENM2,DRD1A,FKBP1B,CCL13,CADM1B,INSL4,ACOX2,LRP6,ICOSLG |
Interacting Protein
PSPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSPN here. Most of them are supplied by our site. Hope this information will be useful for your research of PSPN.
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