PSMB3
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Official Full Name
proteasome (prosome, macropain) subunit, beta type, 3 -
Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12. -
Synonyms
PSMB3;proteasome (prosome, macropain) subunit, beta type, 3;proteasome subunit beta type-3;HC10 II;MGC4147;C10 II;DELTA;EC 3.4.25.1;LMPY;Macropain delta chain;Macropain subunit beta type 6;MGC5169;Multicatalytic endopeptidase complex delta chain;Prosome subunit beta type 6;proteasome (prosome, macropain) subunit, beta type 3;Proteasome beta 3 subunit;Proteasome chain 13;proteasome component C10 II;Proteasome delta chain;Proteasome subunit beta type 6;Proteasome subunit beta type 6 precursor;Proteasome subunit Y;Proteasome theta chain;PSMB6;proteasome component C10-II;HC10-II
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Human
- Mammalian Cell
- HEK293
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
PSMB3 involved in several pathways and played different roles in them. We selected most pathways PSMB3 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMA3,PSMB7,PSMA6A,PSMD6,PSMD11B,PSMD11A,PSMB8,SHFM1,PSME2,PSMD12 |
Protein Function
PSMB3 has several biochemical functions, for example, protein binding,threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMB3 itself. We selected most functions PSMB3 had, and list some proteins which have the same functions with PSMB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MC2R,BAX,GLMN,NHLH2,NBL1,SMNDC1,DUT,COIL,GRK6,DLC1 |
| threonine-type endopeptidase activity | PSMA6A,PSMA5,PSMA1,PRSS50,PSMA7,PSMB4,PSMB11,PSMA3,TASP1,PSMA6 |
Interacting Protein
PSMB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMB3.
UCHL5;TRIM27;PSMB1;PSMB5;PSMB2;POMP;PSMA7;EIF1B;GH1
Resources
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References
- Nandi, D; Woodward, E; et al. Intermediates in the formation of mouse 20S proteasomes: Implications for the assembly of precursor beta subunits. EMBO JOURNAL 16:5363-5375(1997).
