PRKCQ

  • Official Full Name

    protein kinase C, theta

  • Overview

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

  • Synonyms

    PRKCQ;protein kinase C, theta;protein kinase C theta type;PRKCT;nPKC-theta;MGC126514;MGC141919

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Sf9 Insect Cell
  • Insect cell
  • HEK293
  • Insect (sf21)
  • GST
  • His
  • His&GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRKCQ-301488H Recombinant Human PRKCQ protein, GST-tagged E.coli Human GST Met1-Arg145
PRKCQ-3942H Recombinant Human PRKCQ protein, His-tagged E.coli Human His 1-145 aa
PRKCQ-2704H Recombinant Human PRKCQ protein, His & GST-tagged E.coli Human His&GST Phe380~Phe634
PRKCQ-30178TH Recombinant Human PRKCQ Human Non Full L.
PRKCQ-3607R Recombinant Rhesus monkey PRKCQ Protein, His-tagged Mammalian Cell Rhesus macaque His
PRKCQ-408H Active Recombinant Full Length Human Protein Kinase C, Theta, GST-tagged Sf9 Insect Cell Human GST Full L. 1-706 a.a.
PRKCQ-5522Z Recombinant Zebrafish PRKCQ Mammalian Cell Zebrafish His
PRKCQ-916H Recombinant Human Protein Kinase C, Theta, His-tagged Insect cell Human His 2-706 a.a.
PRKCQ-1416HCL Recombinant Human PRKCQ cell lysate Human Non
PRKCQ-3425R Recombinant Rhesus Macaque PRKCQ Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PRKCQ-3425R-B Recombinant Rhesus Macaque PRKCQ Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PRKCQ-5515HF Active Recombinant Full Length Human PRKCQ Protein, GST-tagged Insect (sf21) Human GST Full L. 1-706
PRKCQ-5995H Recombinant Human PRKCQ Protein (Phe380-Phe634), N-GST tagged E.coli Human GST Phe380-Phe634

    Involved Pathway

    PRKCQ involved in several pathways and played different roles in them. We selected most pathways PRKCQ participated on our site, such as NF-kappa B signaling pathway,Vascular smooth muscle contraction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway CARD11,GM1987,BLNK,CCL4L2,TRAF2,TNF,LTB,IL-8,NFKB2,MAP3K7
    T cell receptor signaling pathway MAPK9,GRB2,CD3D,MUC1,CD40LG,PIK3CG,PIK3R1,PIK3R3,KRAS,PTPN6
    Measles PIK3R3,IFNA16,MAVS,NFKBIB,IFNA12,IRF3,Fasl,CCND1,CD3G,STAT3
    Insulin resistance CREB3L3,MTOR,FOXO1B,PRKCB,INSB,PRKCZ,RPS6KA3,PTENB,PTPN11,PPP1R3CA
    Adipocytokine signaling pathway MAPK9,PPARAB,RXRGB,PRKAB1B,PPARA,POMC,NFKBIA,POMCA,TNF,TRAF2
    Inflammatory mediator regulation of TRP channels MAPK9,CYP4A12A,PLA2G4A,P2RY2,CALML5,BDKRB1,CYP2C37,PPP1CB,PRKACB,ASIC3
    Tight junction MYH7B,ASH1L,PPP2R1B,MAGI1B,CLDN11A,CASKA,ACTB1,MPDZ,CRB3A,CSNK2A2A
    Vascular smooth muscle contraction PRKG1A,PPP1R14AA,AGTR1B,KCNMB4,Adcy4,PRKCHA,PLA2G12B,PRKACAB,PRKACA,RHOAC

    Protein Function

    PRKCQ has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCQ itself. We selected most functions PRKCQ had, and list some proteins which have the same functions with PRKCQ. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RPS6KA1,VARS2,ENTPD8,ABCG4B,TAE1,PAK2,PINK1,CHD6,EHD4,ERCC3
    metal ion binding TRAF4A,TRIM35-34,B3GAT1,ANKMY2,RC3H2,ZC3H11A,KLF12A,MMP14B,SDF4,DMRT3A
    protein kinase C activity PRKCH,PRKCA,PKN3,PKN2,PRKCB,PRKCI,PRKCDA,PRKD1,PRKCBB,PRKCE
    ubiquitin-protein transferase activity TRAF7,PDZRN3B,FBXO7,BIRC5B,PARK2,UHRF2,RNF217,UBE2R2,SHPRH,TRIM32
    protein serine/threonine kinase activity ADCK4,RIPK4,VRK1,SRPK2,SNRKB,MAPK14A,CSNK2A2,ACVR1L,ROCK2B,MAPK12B
    protein binding COMP,IFT57,MCM6,IFT20,PPFIA2,NR0B1,TPRGL,FGF7,FOXH1,PIH1D1

    Interacting Protein

    PRKCQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCQ here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCQ.

    FYN;MAP4K3;N/A;GLRX3;PRKCZ

    Resources

    Research Area

    Intracellular Kinases in the Akt Pathway
    PKC Isoforms
    Wnt Intracellular Signaling
    Intracellular Signaling Molecules in Angiogenesis
    Natural Killer T (NKT) Cells

    References

    • Ovsyannikova, IG; Kennedy, RB; et al. Genome-wide association study of antibody response to smallpox vaccine. VACCINE 30:4182-4189(2012).
    • Zheng, YB; Zhang, WS; et al. Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70(S6K) activities in the liver of obese Zucker rats. JOURNAL OF ENDOCRINOLOGY 203:337-347(2009).

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