PRCP
-
Official Full Name
prolylcarboxypeptidase (angiotensinase C) -
Overview
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PRCP;prolylcarboxypeptidase (angiotensinase C);lysosomal Pro-X carboxypeptidase;HUMPCP;PCP;Angiotensinase C;Lysosomal carboxypeptidase C;Lysosomal Pro x carboxypeptidase;MGC2202;PCP_HUMAN;Proline carboxypeptidase;Prolylcarboxypeptidase;prolylcarboxypeptidase isoform 1 preproprotein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- His&T7
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
PRCP involved in several pathways and played different roles in them. We selected most pathways PRCP participated on our site, such as Renin-angiotensin system,Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | KCNE3,COL6A4,KCNJ13,PGA5,ATP1B3,FXYD2,ATP1B4,SLC36A1,MEP1A,SLC8A2 |
| Renin-angiotensin system | LNPEP,ATP6AP2,AGTR1A,KLK1B9,CTSA,KLK2,MRGPRD,KLK1B3,KLK1B8,CMA1 |
Protein Function
PRCP has several biochemical functions, for example, dipeptidyl-peptidase activity,protein binding,serine-type carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRCP itself. We selected most functions PRCP had, and list some proteins which have the same functions with PRCP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COG4,SUN2,C1QTNF9,ZNF263,UBA7,CASK,TESK1,PES1,CLN3,TIRAP |
| dipeptidyl-peptidase activity | FAP,DPP7,DPEP2,DPP3,DPEP3,DPP4,DPP8,NAALAD2,DPEP1 |
| serine-type carboxypeptidase activity | CPM,SCPEP1,CPN1,CPD,CPVL,SENP2,DPP7,CPE,CPZ,CPDB |
Interacting Protein
PRCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRCP here. Most of them are supplied by our site. Hope this information will be useful for your research of PRCP.
GPR37L1;AGT;VDR;q5nhh2_fratt;HNRNPH2;Fus;Ppp2r1a;Smad3
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