PPP1R17
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Official Full Name
protein phosphatase 1, regulatory subunit 17 -
Overview
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
chromosome 7 open reading frame 16;GSBS;G-substrate;OTTHUMP00000158793;OTTHUMP00000202600
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP1R17-0134H | Recombinant Human PPP1R17 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| PPP1R17-13226M | Recombinant Mouse PPP1R17 Protein | Mammalian Cell | Mouse | His |
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| PPP1R17-7974HCL | Recombinant Human C7orf16 293 Cell Lysate | HEK293 | Human | Non |
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| PPP1R17-3433HF | Recombinant Full Length Human PPP1R17 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 155 amino acids |
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| PPP1R17-3675H | Recombinant Human PPP1R17 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Ppp1r17-5067M | Recombinant Mouse Ppp1r17 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PPP1R17-7011M | Recombinant Mouse PPP1R17 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPP1R17-7011M-B | Recombinant Mouse PPP1R17 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPP1R17 involved in several pathways and played different roles in them. We selected most pathways PPP1R17 participated on our site, such as Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | ARAF,PLCB3,PRKG1,MAP2K1,CRH,PLCB1,KRAS,GNAQ,PLA2G4F,NRAS |
Protein Function
PPP1R17 has several biochemical functions, for example, protein serine/threonine phosphatase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R17 itself. We selected most functions PPP1R17 had, and list some proteins which have the same functions with PPP1R17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase inhibitor activity | PPP1R11,PPP1R14C,PPP1R1C,PPP1R8,PPP1R1A |
Interacting Protein
PPP1R17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R17 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R17.
Resources
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References
- Iizuka, M; Murata, T; et al. Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 300:G1010-G1021(2011).
- Murthy, KS; Zhou, HP; et al. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via G(i3), Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. BIOCHEMICAL JOURNAL 374:145-155(2003).
