PPM1L

  • Official Full Name

    protein phosphatase, Mg2+/Mn2+ dependent, 1L

  • Overview

    PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other;phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs;regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular;stimuli (Jin et al., 2004 (PubMed 15560375)).

  • Synonyms

    PPM1L;protein phosphatase, Mg2+/Mn2+ dependent, 1L;protein phosphatase 1 (formerly 2C) like;protein phosphatase 1L;PP2CE;PP2Cepsilon;Protein phosphatase 2C epsilon isoform;PP2C epsilon;protein phosphatase 2C isoform epsilon;PPM1-LIKE;PP2C-epsilo

Recombinant Proteins

  • Mouse
  • Human
  • Bovine
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • E.coli expression system
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PPM1L-13204M Recombinant Mouse PPM1L Protein Mammalian Cell Mouse His
PPM1L-80H Recombinant Human PPM1L protein, His-tagged E.coli Human His 196aa(including fusion tag)
PPM1L-2956HCL Recombinant Human PPM1L 293 Cell Lysate HEK293 Human Non
Ppm1l-5052M Recombinant Mouse Ppm1l Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PPM1L-6995M Recombinant Mouse PPM1L Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PPM1L-6995M-B Recombinant Mouse PPM1L Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL18794BF Recombinant Full Length Bovine Protein Phosphatase 1L(Ppm1L) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (1-360)

    Involved Pathway

    PPM1L involved in several pathways and played different roles in them. We selected most pathways PPM1L participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid de novo biosynthesis SPTLC1,CERS3B,FA2H,PPM1LA,GDF1,COL4A3BP,CERS4A,SGMS2,PPM1LB,ACER1
    Sphingolipid metabolism PPAP2C,ARSI,GDF1,SMPD4,FA2H,SGMS2,SPTLC3,UGT8,GLTPD1,SPHK2
    Metabolism of lipids and lipoproteins FABP12,THEM5,CERS4A,CDS1,AGPAT6,GLTP,MED18,FABP1B.1,MED31,ACER1
    Metabolism SLC44A5B,ALOX5B.3,HS3ST4,NUDT3B,SIN3B,DPYS,SLC25A15A,DCK,SLC4A1A,SCP2B

    Protein Function

    PPM1L has several biochemical functions, for example, metal ion binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1L itself. We selected most functions PPM1L had, and list some proteins which have the same functions with PPM1L. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding PDE6B,SMPD2,POGZ,TIMP1,ZNF707,RFK,RXFP1,STEAP2,ANKZF1,KLF6
    protein serine/threonine phosphatase activity PPM1NB,PPM1AB,PPM1LB,PPM1N,PPM1F,CDC14AA,PPEF2,PPP2R5D,CDC14AB,TAB1

    Interacting Protein

    PPM1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1L here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1L.

    Resources

    Research Area

    Phosphatases and Regulators
    Adherens Junction Proteins in Endothelial Cells
    Adherens Junction Proteins in VSMC

    References

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