POT1
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Official Full Name
protection of telomeres 1 -
Overview
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] -
Synonyms
POT1;protection of telomeres 1;HPOT1;protection of telomeres protein 1;protection of telomeres 1 homolog;POT1-like telomere end-binding protein
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli
- Cell Free System
- HEK293T
- In Vitro Cell Free System
- Non
- His
- Flag
- His&Fc&Avi
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POT1-27935TH | Recombinant Human POT1 | Wheat Germ | Human | Non | 1-95 a.a. |
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| POT1-7115C | Recombinant Chicken POT1 | Mammalian Cell | Chicken | His |
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| POT1-8074Z | Recombinant Zebrafish POT1 | Mammalian Cell | Zebrafish | His |
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| POT1-3005HCL | Recombinant Human POT1 293 Cell Lysate | HEK293 | Human | Non |
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| POT1-141HFL | Active Recombinant Full Length Human POT1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| POT1-1737H | Recombinant Human POT1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| POT1-1737H-B | Recombinant Human POT1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| POT1-2608H | Recombinant Human POT1 Protein, His-tagged | E.coli | Human | His | Met1-Ala177 |
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| POT1-2787H | Recombinant Full Length Human POT1 Protein, Isoform 1, GST-tagged | Cell Free System | Human | GST | Full L. 1-634 a.a. |
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| POT1-2788H | Recombinant Full Length Human POT1 Protein, Isoform 1, Flag-tagged | HEK293 | Human | Flag | Full L. 1-634 a.a. |
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| POT1-5057H | Recombinant Human POT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| POT1-6798HF | Recombinant Full Length Human POT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 634 amino acids |
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Involved Pathway
POT1 involved in several pathways and played different roles in them. We selected most pathways POT1 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with POT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Packaging Of Telomere Ends | TINF2,ACD,TERF1,TERF2,POT1A |
| Cellular responses to stress | TXNRD2,TINF2,TERF2IP,EGLN2,CABIN1,SCMH1,PTGES3,CDKN2C,CBX8A,CHMP4C |
| Cellular Senescence | BMI1A,EP400,HIRA,CEBPB,UBN1,POT1A,CBX8,CBX8A,HMGA1-RS1,HIST3H2BB |
| Cell cycle | UBE2V2,RANGAP1B,MCM6L,PCNA,ARPP19,DULLARD,TUBGCP5,BORA,E2F6,CEP78 |
| DNA Damage/Telomere Stress Induced Senescence | HIRA,EP400,HMGA1-RS1,ASF1A,TERF2,HIST1H1B,H1F0,TINF2,HMGA1B,HTATIP |
| Meiotic synapsis | SYNE2,TERF1,SYCE1,FKBP6,TINF2,SYCP2,SUN2,TERF2,STAG1,STAG2 |
| Meiosis | TEX15,TERF1,DMC1,SYCE1,TINF2,MSH5,SYCP2,TERF2,FKBP6,SYNE1 |
| Chromosome Maintenance | TERF2IP,CENPW,CENPI,TINF2,CENPP,CENPH,TERF2,RUVBL2,WRAP53,NPM1 |
Protein Function
POT1 has several biochemical functions, for example, DEAD/H-box RNA helicase binding,G-rich strand telomeric DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POT1 itself. We selected most functions POT1 had, and list some proteins which have the same functions with POT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-rich strand telomeric DNA binding | CDAN1,POT1A,CTC1 |
| DEAD/H-box RNA helicase binding | ETV3,AKAP8L,POT1A |
| single-stranded telomeric DNA binding | OBFC1,HNRNPA2B1,POT1A |
| telomerase inhibitor activity | MCRS1,POT1A,PINX1 |
| protein binding | PAN2,CACNA1SB,SH3BP4,PROL1,FES,MPL,CPT1B,SHKBP1,NBR1,GINS2 |
Interacting Protein
POT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POT1.
ACD;TERF2;CFL2;TINF2;TERF2IP
Resources
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References
- Singh, U; Maturi, V; et al. Evidence for multiple forms and modifications of human POT1. DNA REPAIR 12:876-877(2013).
- Qing, YF; Zhou, JG; et al. Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL 32:2503-2510(2012).
