POLR2A
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Official Full Name
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -
Overview
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] -
Synonyms
POLR2A;polymerase (RNA) II (DNA directed) polypeptide A, 220kDa;RPB1;RPO2;POLR2;POLRA;RPBh1;RPOL2;RpIILS;hsRPB1;hRPB220;DNA-directed RNA polymerase II subunit RPB1;RNA polymerase II subunit B1;DNA-directed RNA polymerase II subunit A;RNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase III largest subunit;DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
Recombinant Proteins
- Human
- Mouse
- E.coli
- HeLa
- Mammalian Cell
- HEK293
- E. coli
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLR2A-1149H |
Active Recombinant Human POLR2A, CT Domain
|
E.coli | Human | Non | ||
| POLR2A-1148H |
Active Human POLR2A
|
HeLa | Human | Non |
|
|
| POLR2A-2513H |
Active Recombinant Human POLR2A, CT Domain, His-tagged
|
E.coli | Human | His |
|
|
| POLR2A-8461H |
Active Recombinant Human POLR2A, His-tagged
|
E.coli | Human | His |
|
|
| POLR2A-13091M | Recombinant Mouse POLR2A Protein | Mammalian Cell | Mouse | His |
|
|
| POLR2A-29986TH | Recombinant Human POLR2A, His-tagged | E.coli | Human | His |
|
|
| POLR2A-30767TH | Recombinant Human POLR2A | E.coli | Human | Non | 580 amino acids |
|
| POLR2A-3037HCL | Recombinant Human POLR2A 293 Cell Lysate | HEK293 | Human | Non |
|
|
| POLR2A-10H | Recombinant Human POLR2A protein, His-tagged | E. coli | Human | His | Ile1231-Lys1350 |
|
| POLR2A-6920M | Recombinant Mouse POLR2A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| POLR2A-6920M-B | Recombinant Mouse POLR2A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
POLR2A involved in several pathways and played different roles in them. We selected most pathways POLR2A participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | PRIM2,NME7,UPB1,DPYDB,NT5C1B,POLR3B,UCK2,NT5C3B,TXNRD1,CMPK |
| Huntingtons disease | Atp5g2,NDUFB6,NDUFA3,POLR2J2,TP53,NDUFV2,HDAC2,DNAH5,COX8A,PLCB2 |
| Epstein-Barr virus infection | PIK3CB,IRF3,NCOR2,EIF2AK1,YWHAG,HLA-A,MAP3K14,RELA,HLA-DRB3,HSPA1B |
| RNA polymerase | POLR2K,POLR2GL,POLR3K,ZNRD1,POLR1E,POLR2C,POLR1A,POLR3B,POLR2D,POLR1C |
| Metabolic pathways | NTPCR,RRM1,ATP6V1G2,GPAM,CYP2C19,MTMR14,AADAT,GBA3,GRHPRB,GLB1 |
| Purine metabolism | NUDT16,POLR3D,PRPS1L1,CECR1,AK3,NT5C1A,PAPSS1,AK4,PKM2,CANT1 |
| Herpes simplex infection | HMGN1,EEF1D,CDC34A,SRSF6B,BLB2,HLA-DQA1,MHC2DAB,HLA-DRB3,IFNA12,CUL1 |
Protein Function
POLR2A has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2A itself. We selected most functions POLR2A had, and list some proteins which have the same functions with POLR2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | H2-AB1,HSPA5,NPLOC4,CUL5,FAF1,EIF4E2,ABI2,HM13,TANK,UBE2KA |
| contributes_to RNA polymerase II activity | POLR2E,POLR2K,POLR2C,POLR2J,POLR2B,POLR2J3,POLR2F,POLR2J2,POLR2EB,POLR2L |
| DNA binding | ZBED4,RMI2,TP53,ZNF18,ZNF146,HIST4H4,MB21D2,ZNF577,TMPOB,BARHL1A |
| DNA-directed RNA polymerase activity | POLR2EB,POLR2J,CRCP,POLR2I,POLR2M,POLR3C,MED21,POLR3F,CCDC111,POLR3G |
| poly(A) RNA binding | RPS21,RPL5B,IFI203,BRIX1,PPP1R10,RBM12B,SLIRP,PWP2,MTDH,PAN3 |
| contributes_to protein binding | TGFBR3,MEF2A,TAF10,PAK1,INTS10,INHA,ACVR2A,CRY1A,MLH1,MSH6 |
| metal ion binding | ZBTB49,ZFP574,CYCS,POLL,CYP17A2,TGM2,TRIM36,ACMSD,FHL1B,ZFP13 |
| protein binding | SMARCD1,AIMP2,NAT2,REEP1,BAK1,TFF2,SUDS3,CNPY2,AP2A2,NPEPL1 |
Interacting Protein
POLR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2A.
SUPT5H;PAF1;DDX5;RPRD1B;CDC73
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References
- Yamada, K; Hayashi, M; et al. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription. PLOS ONE 8:-(2013).
- Komashko, VM; Acevedo, LG; et al. Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells. GENOME RESEARCH 18:521-532(2008).
