POLE3
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Official Full Name
polymerase (DNA directed), epsilon 3, accessory subunit -
Overview
Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. -
Synonyms
Arsenic transactivated protein;Arsenic-transactivated protein;ASTP;CHARAC 17;CHARAC17;CHRAC 17;CHRAC-17;CHRAC17;Chromatin Accessibility Complex 17;Chromatin accessibility complex 17 kDa protein;DNA Polymerase Epsilon p17 Subunit;DNA polymerase epsilon subunit 3;DNA polymerase epsilon subunit p17;DNA polymerase II subunit 3;DPOE3_HUMAN;Histone fold protein CHRAC17;HuCHRAC 17;HuCHRAC17;p17;p17 subunit;POL E3;POLE 3;POLE3;Polymerase (DNA directed) epsilon 3;YBL 1;YBL1;DNA Polymerase Epsilon (Pol Epsilon)
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Human
- Rhesus macaque
- Rat
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
POLE3 involved in several pathways and played different roles in them. We selected most pathways POLE3 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | FZD8,CRTC3,PPP3R1,MAP3K3,ATF1,EP300,PRKACG,WNT3,HLA-DPB1,APC2 |
| Base excision repair | HMGB1,XRCC1,MUTYH,POLE2,POLD2,mutY,TDG.1,POLD3,HMGB1A,MBD4 |
| DNA Replication | RNASEH2A,MCM4,RPA1,GINS3,GINS1,RFC4,rnhA,MCM6L,MCM5,POLD1 |
| Pyrimidine metabolism | PRIM2,POLR2L,POLR2J3,NME2B.1,ENTPD3,POLR3A,UCK2B,POLR1B,NT5C3B,CANT1B |
| Nucleotide Excision Repair | ERCC6,RFC1,XPC,GTF2H3-2,INO80E,ZFP830,RPA1,BIVM-ERCC5,ERCC2,POLE2 |
| Metabolic pathways | ALDH5A1,PAFAH1B2,PIGO,RDH8,SPAM1,PKM,PLCG2,UGT2B15,HMGCRA,NME2B.2 |
| Purine metabolism | PDE8B,NT5C2B,PDE3A,POLR3GLB,Adcy4,PFAS,PAPSS1,PKMA,TWISTNB,APRT |
Protein Function
POLE3 has several biochemical functions, for example, DNA binding,DNA-directed DNA polymerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE3 itself. We selected most functions POLE3 had, and list some proteins which have the same functions with POLE3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-directed DNA polymerase activity | CCDC111,MYBBP1A,POLM,POLE4,PRIMPOL,POLN,POLA1,POLK,POLD2,POLI |
| DNA binding | TCEB3,ONECUT1,ZNF620,PAX1A,HUWE1,NFE2L1A,NR1H3,RX1,ZIC2,MAFGA |
| protein heterodimerization activity | CRLF1,PDSS1,MEF2C,GTF2A2,NAE1,SRI,NR4A2,SMAD1,PKNOX1,ANO9A |
| protein binding | DNER,EIF4H,TOMM20,EIF4A1,HIRIP3,GLRA1,SRGAP2,RBBP8,USP12,WRAP53 |
Interacting Protein
POLE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE3.
DRAP1;CHRAC1;DKFZp666G145;ORF;POLE4
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