PMP22
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Official Full Name
peripheral myelin protein 22 -
Overview
PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in the compact myolin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot-Marie-Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies. -
Synonyms
PMP22;peripheral myelin protein 22;GAS 3;HNPP;Sp110;PMP-22;growth arrest-specific 3;growth arrest-specific protein 3;DSS;CMT1A;CMT1E;GAS-3;HMSNIA;MGC20769
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Pongo Abelii
- Horse
- Bovine
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- HEK293
- In vitro E. coli expression system
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- GST
- His&SUMO
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
- His&GST
- Flag
Involved Pathway
PMP22 involved in several pathways and played different roles in them. We selected most pathways PMP22 participated on our site, such as Neural Crest Differentiation,a6b1 and a6b4 Integrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMP22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neural Crest Differentiation | HOXA1,DLX5,CTBP2,CDH6,LHX1,LHX2,MYB,OLIG1,ZIC1,TFAP2B |
| a6b1 and a6b4 Integrin signaling | MST1,MST1R |
Protein Function
PMP22 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMP22 itself. We selected most functions PMP22 had, and list some proteins which have the same functions with PMP22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SCRN2,RIPPLY1,EPM2A,TRAPPC4,ARHGEF12,C19orf57,Abcb1b,KCTD14,NDEL1,CDK5R2 |
Interacting Protein
PMP22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMP22 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMP22.
KLRC1;SMIM3;tyrB;gltD1;DDX52
Resources
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References
- Kalantari-Dehaghi, M; Anhalt, GJ; et al. Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique. PLOS ONE 8:-(2013).
- Homs, J; Ariza, L; et al. Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration. GENE THERAPY 18:622-630(2011).
