PLEC
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Official Full Name
plectin -
Overview
Plectin interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. -
Synonyms
PLEC1;Plectin-1;Hemidesmosomal protein 1;plectin;PLTN;PCN;plectin 1, intermediate filament binding protein 500kDa;HD1;EBS1;epidermolysis bullosa simplex 1 (Ogna);plectin 1, intermediate filament binding protein, 500kD;EBSO;PLEC1b;LGMD2Q;OTTHUMP00000229282;OTTHUMP00000229283;OTTHUMP00000229284;OTTHUMP00000229285;OTTHUMP00000229286;OTTHUMP00000229287;OTTHUMP00000229288;PLEC
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLEC-1837H | Recombinant Human PLEC protein, GST-tagged | E.coli | Human | GST | 1475-1768 aa | |
| PLEC1-32H | Recombinant Human PLEC Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| PLEC-1357H | Recombinant Human PLEC Protein, His-tagged | E.coli | Human | His | 175-400 a.a. |
|
| PLEC-30873TH | Recombinant Human PLEC, His-tagged | E.coli | Human | His | 4045-4505 a.a. |
|
| PLEC-32H | Recombinant Human PLEC Protein, GST-tagged | Wheat Germ | Human | GST | 4384 a.a. - 4493 a.a. |
|
| PLEC-1877H | Recombinant Human PLEC protein, His-tagged | HEK293 | Human | His | Ala 4377 - Ala 4684 |
|
Involved Pathway
PLEC involved in several pathways and played different roles in them. We selected most pathways PLEC participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway,Apoptosis,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | CLDN20,CDH10,CDH3,ITGB1B.1,CDH6,CDH17,CDH4,CLDN7,ANG,CDH11 |
| Apoptotic cleavage of cellular proteins | DBNLB,CASP8L1,DBNL,BCAP31,PKP1,CLSPN,GAS2,DSP,BMX,DSG1 |
| Apoptotic execution phase | HMGB2,DSG3,DBNLB,DSG1,PTBP3,CASP6L2,BMX,H1F0,STK24B,PKP1 |
| Alpha6-Beta4 Integrin Signaling Pathway | DST,EIF4EBP1,NTN1A,DSP,CLCA1,YWHAQ,EIF4E,SMAD3B,EIF4EB,MST1R |
| Cell-Cell communication | LIMS1,CDH10A,CTNND1,CDH9,SPTBN1,CDH12,COL17A1,CDH8,NPHS1,KIRREL3 |
| Apoptosis | CDKN2A,IRF2,CASP9,PIK3R2,BCL2L1,CAPN2B,TRP53,PPP3R2,Casp3,CAPN1 |
| Caspase-mediated cleavage of cytoskeletal proteins | GAS2,CASP6L2,DBNLA,VIML,DBNLB,SPNA2,PLECA,ADD1,CASP6L1,DBNL |
| Assembly of collagen fibrils and other multimeric structures | ABHD1,PCOLCE,BMP1B,COL3A1,COL6A1,COL1A2,LOXL4,COL1A1,COL10A1A,COL5A2 |
Protein Function
PLEC has several biochemical functions, for example, actin binding,ankyrin binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEC itself. We selected most functions PLEC had, and list some proteins which have the same functions with PLEC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ankyrin binding | OBSCN,SPTBN1,KCNJ11,KCTD6,RHCG,SLC8A1,RHAG,SLC4A1,KCNQ2,SCN5A |
| actin binding | ACTN3A,CAP2,SHANK3,PHACTR3A,PHACTR3,FMN2,CNN2,DBNLB,FHOD3,WHAMM |
| poly(A) RNA binding | ZCCHC17,NME1,SLTM,HLTF,HIST1H1B,RPF1,ERAL1,USP10,MBNL1,PURG |
| structural constituent of muscle | DAG1,NEBL,COX4I2,SMTN,MYL6,MYBPC3,ANKRD2,TPM1,MYBPC2,NEXN |
| protein binding | TARSL2,ILVBL,CIB4,FAM188A,GATA4,EIF3C,SYAP1,CHCHD1,PAK1IP1,NECAB3 |
Interacting Protein
PLEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEC here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEC.
ITGB4;FUS;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;EWSR1;SQSTM1;TSC22D1;PAN2;KCTD13;TAF15;USP20
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