PLCG2
-
Official Full Name
phospholipase C, gamma 2 (phosphatidylinositol-specific) -
Overview
Phospholipase C (PLC) is a class of enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Thirteen kinds of mammalian phospholipase C are classified into six isotypes (β, γ, δ, ε, ζ, η) according to structure. -
Synonyms
PLC-gamma2;PLC;Phospholipase C;PLCG2;phospholipase C, gamma 2 (phosphatidylinositol-specific)
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PLCG2 involved in several pathways and played different roles in them. We selected most pathways PLCG2 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | CCND1,ERBB2,PIK3R2,AKT1,AKT2,STK4,SOS1,PIK3CB,HRAS,NRAS |
| Metabolic pathways | GALNT12,MUT,LASS5,AGXT2L2,ACSS2L,LCT,DHFRL1,PPAP2C,GLDC,HSD17B6 |
| Natural killer cell mediated cytotoxicity | KRAS,MAP2K1,ZAP70,SHC4,GZMB,MAPK1,HRAS,SH3BP2,IFNA13,HCST |
| Phosphatidylinositol signaling system | MTMR4,PLCD1B,TMEM55B,ITPK1A,PLCG1,INPPL1A,PPIP5K2,CALM3B,PIK3R1,DGKZ |
| Osteoclast differentiation | SPI1,TREM2,SIRPA,TYK2,IFNGR2,CSF1,IFNB1,PPP3CB,LCP2,AKT2 |
| Proteoglycans in cancer | ERBB4,RRAS2,HPSE2,ARHGEF12,FGFR1,ACTG1,CAV2,PIK3CB,SLC9A1,SOS1 |
| Pathways in cancer | FZD1,FGF11,WNT8B,TRP53,DAPK1,BCL2,CCNE1,GNGT1,IKBKB,PRKACA |
| Calcium signaling pathway | CHRNA7,CACNA1D,PDGFRB,TNNC2,SLC25A31,CHRM2,ADRa1A,CAMK2D2,ATP2B3B,ATP2B2 |
| Epithelial cell signaling in Helicobacter pylori infection | CXCR2,ATP6V1G1,JAM2,IL-8,ATP6V1C1,CCL5,ATP6AP1,ATP6V1C2,GIT1,CDC42 |
Protein Function
PLCG2 has several biochemical functions, for example, phosphatidylinositol phospholipase C activity,phospholipase C activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCG2 itself. We selected most functions PLCG2 had, and list some proteins which have the same functions with PLCG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLXDC1,TCEB3B,ACAT2,F7,TPM3,MYH10,GMCL1P1,MAP3K8,RPL39L,RLTPR |
| phosphatidylinositol phospholipase C activity | EDNRA,PLCL2,CCL5,PLCB3,PLCD3,PLCL1,PLCD4,PLCD3A,CASR,PLCD1B |
| signal transducer activity | HTR1D,GRM6B,O3far1,LPAR6,TICAM2,DRD4A,RRH,OLFR488,SP110,LGALS9 |
| phospholipase C activity | PLCB2,PDIA3,ADORA1,PLCE1,PLCB4,PLCH2,PLCB3,PLCG1,PLCL1 |
Interacting Protein
PLCG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCG2.
EGFR;ERBB2;PIK3R1;PSMD3;FSBP;PTTG1;TP53;HSPD1
PLCG2 Related Signal Pathway
Resources
Related Services
Related Products
References
- Chae, JJ; Park, YH; et al. Connecting Two Pathways Through Ca2+ Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation. ARTHRITIS & RHEUMATOLOGY 67:563-567(2015).
- Wang, J; Sohn, H; et al. The autoinhibitory C-terminal SH2 domain of phospholipase C-gamma 2 stabilizes B cell receptor signalosome assembly. SCIENCE SIGNALING 7:-(2014).
