PLA2G3
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Official Full Name
phospholipase A2, group III -
Overview
PLA2G3 belongs to the family of secreted phospholipase A2 (sPLA2; EC 3.1.1.4) proteins. These Ca(2+)-dependent;lipolytic enzymes have a conserved Ca(2+)-binding loop and a his-asp dyad in the catalytic site (Murakami et al., 2003;(PubMed 12522102)). -
Synonyms
PLA2G3;phospholipase A2, group III;group 3 secretory phospholipase A2;GIII SPLA2;sPLA2-III;group III secreted phospholipase A2;group III secretory phospholipase A2;phosphatidylcholine 2-acylhydrolase 3;phosphatidylcholine 2-acylhydrola
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLA2G3-118H | Recombinant Human PLA2G3 Protein, His-tagged | E.coli | Human | His |
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| Pla2g3-8260R | Recombinant Rat Pla2g3 protein, His & T7-tagged | E.coli | Rat | His&T7 | Gly20~Leu268 |
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| PLA2G3-3142HCL | Recombinant Human PLA2G3 293 Cell Lysate | HEK293 | Human | Non |
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| PLA2G3-01H | Recombinant Human PLA2G3 Protein, GST-tagged | Wheat Germ | Human | GST | 21-130 |
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| PLA2G3-119H | Recombinant Human PLA2G3 protein, His-tagged | E.coli | Human | His | 20-268 a.a. |
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Involved Pathway
PLA2G3 involved in several pathways and played different roles in them. We selected most pathways PLA2G3 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | FGF22,HTR7,GNG8,FGF21,GRIN2B,KSR2,HGF,RRAS2,FGF6,ELK1 |
| alpha-Linolenic acid metabolism | ACAA1A,PLA2G6,PLA2G2A,PLA2G2E,ACOX1,ACAA1,PLA2G10,PLA2G4D,PLA2G4F,PLA2G12B |
| Pancreatic secretion | RAB3D,PNLIPRP1,CELA3A,CTRB1,ATP2B4,BST1,ATP1A4,KCNQ1,Car2,CELA3B |
| Ether lipid metabolism | PLA2G12A,CEPT1,AGPS,PLD2,PLB1,PLD1A,PAFAH2,PAFAH1B1A,PLA2G5,CHPT1 |
| Linoleic acid metabolism | CYP3A41A,CYP2C55,ALOX15,PLA2G6,PLA2G4A,PLB1,PLA2G4D,PLA2G4C,CYP2J2,CYP2J6 |
| Fat digestion and absorption | PLA2G5,PLA2G2E,PLA2G2D,PLA2G1B,MOGAT3,MOGAT2,APOB,ABCG8,Cel,FABP1 |
| Glycerophospholipid metabolism | GPD2,MBOAT2B,PPAP2A,DGKZ,CHKA,PPAP2B,LPCAT3,DGKAA,CHAT,GPCPD1 |
| Vascular smooth muscle contraction | CALM3,PRKCBB,PRKACG,PPP1CC,AVPR1B,CACNA1DA,CALM2B,PRKCHA,PLA2G4D,ACTG2 |
| Metabolic pathways | TM7SF2,NOS2A,GAD1B,ACOT2,PIGF,B3GALNT1,GMDS,SGMS2,HADHB,POLD2 |
Protein Function
PLA2G3 has several biochemical functions, for example, calcium-dependent phospholipase A2 activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G3 itself. We selected most functions PLA2G3 had, and list some proteins which have the same functions with PLA2G3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | MOBKL2B,MAN1A,ZNF689,FTR14,TTC4,GTPBP6,SMYD4,ZSCAN4F,PRDM16,ZNRF3 |
| calcium-dependent phospholipase A2 activity | PLA2G4A,PLA2G4B,PLA2G1B,PLA2G12A,PLA2G4F,PLA2G5,PLA2G2A |
Interacting Protein
PLA2G3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G3.
TGFB1I1;PVR
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References
- Sin, BA; Akdis, M; et al. T-cell and antibody responses to phospholipase A(2) from different species show distinct cross-reactivity patterns. ALLERGY 66:1513-1521(2011).
- Tanaseanu, C; Tudor, S; et al. Vascular endothelial growth factor, lipoporotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemic lupus erithematosus. EUROPEAN JOURNAL OF MEDICAL RESEARCH 12:145-151(2007).
