PIK3C2B

  • Official Full Name

    phosphoinositide-3-kinase, class 2, beta polypeptide

  • Overview

    The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

  • Synonyms

    PIK3C2B;phosphoinositide-3-kinase, class 2, beta polypeptide;phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta;C2 PI3K;PI3K C2beta;PI3K-C2beta;PI3K-C2-beta;PTDINS-3-kinase C2 beta;ptdIns-3-kinase C2 subunit beta;phosphoi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIK3C2B-1716H Recombinant Human PIK3C2B, His-tagged E.coli Human His 1-350aa
PIK3C2B-1871H Recombinant Human PIK3C2B protein, GST-tagged E.coli Human GST 1-350 aa
PIK3C2B-164H Active Recombinant Human PIK3C2B protein, GST-tagged Insect Cell Human GST 850-end a.a.
PIK3C2B-118H Recombinant Human PIK3C2B, GST-tagged Sf9 Insect Cell Human GST 850-end a.a.
Pik3c2b-1722R Recombinant Rat Pik3c2b protein, His & T7-tagged E.coli Rat His&T7 Ser790~Leu1025
Pik3c2b-4862M Recombinant Mouse Pik3c2b Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    PIK3C2B involved in several pathways and played different roles in them. We selected most pathways PIK3C2B participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phosphatidylinositol signaling system PIP5K1AB,PIP5K1BB,CALM1B,IP6K2,PLCG1,PLCZ1,PLCG2,CALM2A,CDS1,PLCE1
    Metabolic pathways CYP2A12,MTMR1,PTGES3A,B3GNT5B,H2-KE6,HGSNAT,GGPS1,NDUFB1,POLR3G,PLD1A
    Inositol phosphate metabolism PLCD1A,PIK3CD,ITPKB,PLCB1,MTMR7,MTMR1B,PI4K2A,CDIPT,INPP4AB,PIP5K1A

    Protein Function

    PIK3C2B has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2B itself. We selected most functions PIK3C2B had, and list some proteins which have the same functions with PIK3C2B. You can find most of the proteins on our site.

    Function Related Protein
    lipid kinase activity TAE1,DGKZ
    protein binding ZNF622,MPHOSPH8,SOX17,ARMCX5-GPRASP2,NPDC1,SYNE3,WDR77,DIS3L2,LRIF1,FADD
    1-phosphatidylinositol-4-phosphate 3-kinase activity PIK3CB,PIK3CA,PIK3C2G,PIK3CD,PIK3CG,PIK3C2A
    1-phosphatidylinositol-3-kinase activity PIK3C2G,PIK3CA,PIK3C3,PIK3CG,ATM,PIK3R3,PIK3CD,PIK3CB,PIK3C2A
    ATP binding RECQL5,RPS6KC1,PANK1,FLJ11011L,TTLL12,HSPD1,DDX5,PMS1,LONP1,CIT
    phosphatidylinositol binding SH3YL1,MTM1,PLD1,RPS6KC1,P2RX2,SNX22,TULP4A,PLD1A,SNX17,SNX5

    Interacting Protein

    PIK3C2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2B.

    EGFR;TRIM27;GRB2;ERBB2;PDGFRB;NCK1

    Resources

    Research Area

    Apoptosis Intracellular Kinases
    Diabetic Peripheral Neuropathy
    PI 3-Kinases (Phosphoinositide 3-Kinases)
    Apical-basal Polarity Effectors

    References

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