PIK3C2A
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Official Full Name
phosphoinositide-3-kinase, class 2, alpha polypeptide -
Overview
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. -
Synonyms
PIK3C2A;phosphoinositide-3-kinase, class 2, alpha polypeptide;phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha;PI3K C2alpha;PI3K-C2alpha;PI3K-C2-alpha;ptdIns-3-kinase C2 subunit alpha;phosphoinositide 3-kinase-C2-alpha
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIK3C2A-1715H | Recombinant Human PIK3C2A, His-tagged | E.coli | Human | His | 1-338aa | |
| PIK3C2A-1452H |
Active Recombinant Human PIK3C2A, GST-tagged
|
Sf9 Insect Cell | Human | GST | 299 aa-end |
|
| PIK3C2A-551H | Recombinant Human PIK3C2A Protein, His-tagged | E.coli | Human | His | Phe172~Asn403 |
|
| Pik3c2a-552M | Recombinant Mouse Pik3c2a Protein, His/GST-tagged | E.coli | Mouse | His&GST | Lys349~Pro611 |
|
| PIK3C2A-3191HCL | Recombinant Human PIK3C2A 293 Cell Lysate | HEK293 | Human | Non |
|
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| PIK3C2A-3165H | Recombinant Human PIK3C2A Protein (Phe172-Asn403), His tagged | E.coli | Human | His | Phe172-Asn403 |
|
Involved Pathway
PIK3C2A involved in several pathways and played different roles in them. We selected most pathways PIK3C2A participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GDA,TWISTNB,COQ7,PAFAH1B1A,RRM2B,MT-ATP6,PPT2,NAMPTB,LIAS,GCNT1 |
| Inositol phosphate metabolism | PLCB4,SYNJ1,PIKFYVE,INPP5L,INPP5J,MINPP1A,PLCD3,MTMR3,ITPKA,INPPL1 |
| Phosphatidylinositol signaling system | CALML3,ITPKC,PIP5K1AA,PIK3R1,PLCZ1,MTMR1B,INPP1,INPPL1,PTENA,ITPKA |
Protein Function
PIK3C2A has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2A itself. We selected most functions PIK3C2A had, and list some proteins which have the same functions with PIK3C2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol binding | FES,SNX27B,SLC12A9,AKR1C1,ZCCHC2,HIP1R,ING2,PLD1A,SNX18A,SNX1A |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3CA,PIK3CB,PIK3C2G,PIK3CD,PIK3C2B,PIK3CG |
| phosphatidylinositol 3-kinase activity | PIK3CA,PIK3CG,PIK3CD,PIK3CB |
| 1-phosphatidylinositol-3-kinase activity | PIK3C2B,PIK3C2G,PIK3CG,PIK3CB,PIK3C3,ATM,PIK3CA,PIK3CD,PIK3R3 |
| ATP binding | RNASEL,CDK14,ETNK2,CDK20,ABCB1A,ABCA13,VCP,CDKL1,RAF1A,TTF2 |
Interacting Protein
PIK3C2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2A.
Dlg4;ATG7;STAMBP;PGK1;TARS;FKBP4;MAP1LC3A;ANKFY1;PA2G4;AMOT;phoA;purvalanol b;Sec24c;GAK;SEC16A;EGFR;ERBB2;CLTB;FLNA
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References
- Muffak-Granero, K; Olmedo, C; et al. Gene Network Profiling Before and After Transplantation in Alcoholic Cirrhosis Liver Transplant Recipients. TRANSPLANTATION PROCEEDINGS 44:1493-1495(2012).
- Huang, WS; Wang, TB; et al. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. WORLD JOURNAL OF GASTROENTEROLOGY 18:3458-3464(2012).
