PIAS4
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Official Full Name
protein inhibitor of activated STAT, 4 -
Overview
The PIAS (protein inhibitor of activated Stat) proteins, which include PIAS1, PIAS3, PIASx, and PIASy, were originally characterized based on their interaction with the Stat family of transcription factors (1,2). PIAS1, PIAS3, and PIASx interact with and -
Synonyms
PIAS4;protein inhibitor of activated STAT, 4;E3 SUMO-protein ligase PIAS4;FLJ12419;Piasg;PIASY;zinc finger;MIZ type containing 6;ZMIZ6;PIAS-gamma;zinc finger, MIZ-type containing 6;protein inhibitor of activated STAT protein 4;protein inhibito
Recombinant Proteins
- Human
- Mouse
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- Non
- Flag
- His&Fc&Avi
- His
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIAS4-3201HCL | Recombinant Human PIAS4 293 Cell Lysate | HEK293 | Human | Non |
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| PIAS4-1442HFL | Recombinant Full Length Human PIAS4 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| PIAS4-1674H | Recombinant Human PIAS4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PIAS4-1674H-B | Recombinant Human PIAS4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Pias4-1939M | Recombinant Mouse Pias4 Protein, His-tagged | E.coli | Mouse | His | Val12-Leu272 |
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| PIAS4-246H | Recombinant Human PIAS4 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Pias4-4850M | Recombinant Mouse Pias4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PIAS4 involved in several pathways and played different roles in them. We selected most pathways PIAS4 participated on our site, such as NF-kappa B signaling pathway,Ubiquitin mediated proteolysis,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | STAM,PTPN2A,IFNGR1,IL17D,AKT3A,IL21,IL4,IFNA5,FHL1B,IL12RB2 |
| NF-kappa B signaling pathway | BCL2A1A,GM10591,TRAF2,PRKCB,CXCL12,PIDD1,IL-8,GM13304,TRAF3,ZAP70 |
| Ubiquitin mediated proteolysis | CDC16,UBE2W,CDC34A,PIAS1,UBE4A,CBLB,UBA2,SOCS1A,FBXW11,BIRC3 |
Protein Function
PIAS4 has several biochemical functions, for example, DNA binding,SUMO ligase activity,SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS4 itself. We selected most functions PIAS4 had, and list some proteins which have the same functions with PIAS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SUMO ligase activity | PIAS2,PIAS1 |
| ubiquitin protein ligase binding | KDM4A,DTX1,PARK2,RRAGA,TANK,DERL1,NPLOC4,SMAD7,XBP1,PTPN22 |
| protein C-terminus binding | VIM,CTGF,TCF4,DST,PHB2,BCL10,MYO1C,CALCOCO1,PPP2CB,HOMER3 |
| protein binding | COL1A1,BSG,SNRPA1,CLK2,PCBP1,FAM86C,RUNX3,ASCL1,ZFC3H1,PXMP4 |
| ligase activity | BRAP,RNF133,RNF25,MIB1,TRIM27,TRIML2,RNF19A,SH3RF1,CMTM2A,NSMCE1 |
| zinc ion binding | RNF151,RBCK1,TRIM10,PRDM2,TRIM39,RBM4.1,TTC3,RC3H1,KDM5A,MEP1A |
| SUMO transferase activity | UBE2IB,SUMO3,PIAS3,SUMO1,NSMCE2,MUL1,CBX4,UBE2I,TOPORS,UBE2IA |
| DNA binding | TBX4,TEAD1,REV3L,HIST1H4L,E2F6,RAG2,THAP4,ZNF654,ZBTB6,ATXN1L |
Interacting Protein
PIAS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS4.
PARP1;Tp53;TADA3;TP53;HTT;SUMO2;MEN1;PRMT5;XRCC6
PIAS4 Related Signal Pathway
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