PIAS3

  • Official Full Name

    protein inhibitor of activated STAT, 3

  • Overview

    This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined.

  • Synonyms

    PIAS3;protein inhibitor of activated STAT, 3;E3 SUMO-protein ligase PIAS3;FLJ14651;zinc finger;MIZ type containing 5;ZMIZ5;zinc finger, MIZ-type containing 5;protein inhibitor of activated STAT protein 3

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cell
  • HEK293
  • GST
  • His&GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIAS3-1704H Recombinant Human PIAS3, GST-tagged E.coli Human GST 277-628aa
PIAS3-1245H Recombinant Human PIAS3 protein, His & GST-tagged E.coli Human His&GST Val11~Leu280
PIAS3-12770M Recombinant Mouse PIAS3 Protein Mammalian Cell Mouse His
PIAS3-4443R Recombinant Rat PIAS3 Protein Mammalian Cell Rat His
PIAS3-3202HCL Recombinant Human PIAS3 293 Cell Lysate HEK293 Human Non
PIAS3-4103R Recombinant Rat PIAS3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PIAS3-4103R-B Recombinant Rat PIAS3 Protein Pre-coupled Magnetic Beads HEK293 Rat
PIAS3-6719M Recombinant Mouse PIAS3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PIAS3-6719M-B Recombinant Mouse PIAS3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PIAS3 involved in several pathways and played different roles in them. We selected most pathways PIAS3 participated on our site, such as Androgen receptor signaling pathway,C-MYB transcription factor network,Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Global Genome Nucleotide Excision Repair (GG-NER) USP45,INO80B,MCRS1,COPS2,NFRKB,COPS8,ACTL6A,COPS7A,INO80,COPS4
    Formation of Incision Complex in GG-NER RNF111,CETN2,DDB1,PARP2,CHD1L,USP45,DDB2
    DNA Repair SMARCA5,TDP2B,GEN1,PPP4R2,ALKBH2,PARP1,EYA2,ASCC3,COPS5,RAD9A
    Interferon type I GNB2L1
    C-MYB transcription factor network CDK6,GATA1,CEBPB,SKI,ADORA2B,COL1A2,CREBBP,ELANE,TOM1,PPID
    IL6-mediated signaling events JUNB,CRP,LMO4
    Androgen receptor signaling pathway SVILA,PSMC3IP,CARM1,RNF6,RUNX2A,RAD54L2,AES,CMTM2A,DSTN,HTATIP
    Coregulation of Androgen receptor activity PA2G4,KDM3A,SVIL,NRIP1,SNURF,CARM1,CTDSP1,CMTM2A,KDM4C,KDM1A

    Protein Function

    PIAS3 has several biochemical functions, for example, SUMO transferase activity,enzyme binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS3 itself. We selected most functions PIAS3 had, and list some proteins which have the same functions with PIAS3. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding ZFP622,LHX4,EP300,TRIM28,KDM2BA,MICALL2A,HDAC6,CA1,TET2,MMP1A
    enzyme binding MLEC,CBX4,RARA,LYN,DVL1,DDX5,PTPLAD1,STUB1,TOP2B,PHB
    ligase activity ZNRF2,RAD18,SH3RF1,RLIM,RAG1,MDM2,MUL1A,UBE1Y1,UBE2KB,RFFL
    potassium channel regulator activity DRD4,KCNS3,AMIGO1,KCNMB2,ABCC9,DPP6,KCNMB3,PRKCZ,KCNIP4,ADRB2
    protein N-terminus binding ALG2,TBL1XR1,STX5A,ARF6,RBPJ,STX1A,CSNK2A1,NFE2,ACTN4,SDCBP
    protein binding FGB,PYURF,PLIN3,PGR,PYGO1,ASF1B,ECH1,RYK,AKAP8L,TBP
    protein C-terminus binding TAF13,SNTG1,HIC2,TOP2B,HESX1,SREBF2,TCF4,DLG4,MAP3K7,HAND2
    SUMO transferase activity UBE2IA,MUL1,SUMO4,CBX4,NSMCE2,UBE2IB,PIAS4,TOPORS,UBE2I,SUMO3

    Interacting Protein

    PIAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS3.

    MBD1;UBE2I;HNRNPK;GFI1;PRPF40A;SKIL;GLUL;UBA1;STAT3;yscQ;GEMIN4;PPP1CA;PSMC1;SATB1;CREM;SREBF2;q5ni67_fratt

    PIAS3 Related Signal Pathway

    Resources

    Research Area

    Apoptosis Transcription Factors and Regulators
    Ubiquitin-like Modifiers (UBLs) and Regulators
    Post-translational Modification of NFkB/IkB

    References

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