PI4KB
-
Official Full Name
phosphatidylinositol 4-kinase, catalytic, beta -
Overview
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. -
Synonyms
PI4KB;phosphatidylinositol 4-kinase, catalytic, beta;PIK4CB;phosphatidylinositol 4-kinase beta;PI4K BETA;pi4K92;PtdIns 4-kinase beta;type III phosphatidylinositol 4-kinase beta;phosphatidylinositol 4-kinase, wortmannin-sensitive;NPIK;PI4
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Insect (sf21)
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- GST
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PI4KB involved in several pathways and played different roles in them. We selected most pathways PI4KB participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4KB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GBE1,URAD,ATP6V1G1,POLR1C,IMPDH1A,CYP21A1,LIPF,SPTLC1,CYP51,DCK |
| Phosphatidylinositol signaling system | PRKCBB,MTMR14,PIK3CG,DGKAA,MTMR7B,PIK3R3A,PLCD1,OCRL,PTENA,PI4KA |
| Inositol phosphate metabolism | PIK3CD,INPP1,INPP5A,PI4K2A,PIK3C2A,PIK3CA,MTMR7A,INPPL1,MTMR4,PLCG2 |
Protein Function
PI4KB has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity,ATP binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4KB itself. We selected most functions PI4KB had, and list some proteins which have the same functions with PI4KB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CD1B,CTNND1,SH3PXD2A,XAGE3,RPP30,INSR,ENC1,HORMAD1,EYA2,SRSF7 |
| ATP binding | KIF1B,KHK,UHMK1,TLK1B,NLRP14,DSTYK,NOLC1,IRAK1,DGKZ,PL10 |
| 1-phosphatidylinositol 4-kinase activity | PI4KAA,PI4KA,PI4K2B,PI4K2A,PI4KAB |
Interacting Protein
PI4KB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4KB here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4KB.
YWHAQ;YWHAB;YWHAG;ACBD3;NS;xmd8-92;biotin_acyl-p_probe;SFN;UTRN;KBTBD7
Resources
Related Services
Related Products
References
- Stevenson, JM; Perera, IY; et al. A phosphatidylinositol 4-kinase pleckstrin homology domain that binds phosphatidylinositol 4-monophosphate. JOURNAL OF BIOLOGICAL CHEMISTRY 273:22761-22767(1998).
- WONG, K; CANTLEY, LC; et al. CLONING AND CHARACTERIZATION OF A HUMAN PHOSPHATIDYLINOSITOL 4-KINASE. JOURNAL OF BIOLOGICAL CHEMISTRY 269:28878-28884(1994).
