PGK1

What is pgk1 protein?

PGK1 protein, also known as phosphoglycerate kinase 1, is an enzyme that plays a crucial role in glycolysis. It catalyzes the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, generating ATP in the process. PGK1 is found in all tissues and is involved in the production of energy in the form of ATP during cellular metabolism. It is also used as a marker in clinical diagnostics for certain diseases and used as a model protein in biochemical and biophysical studies.

What is the function of pgk1 protein?

Metabolism: It plays a critical role in glycolysis by facilitating the conversion of 1,3-biphosphoglycerate to 3-phosphoglycerate. This helps generate ATP from glucose breakdown.

Energy production: By generating ATP, PGK1 contributes to cellular energy production which is essential for basic metabolic processes and growth.

Glycolysis: It is a major enzyme involved in glycolysis, the process by which glucose is oxidized to pyruvate to produce energy in the presence of oxygen.

Pgk1 related signaling pathway

Glycolysis pathway: PGK1 catalyzes a central reaction (step 7) in glycolysis that generates ATP by converting glucose to pyruvate. This fuels the glycolytic pathway.

PI3K/Akt/mTOR pathway: PGK1 activity supports growth signaling through PI3K/Akt/mTOR by providing ATP and metabolic intermediates for anabolic processes.

HIF-1 pathway: Hypoxia-induced PGK1 upregulation helps stabilize HIF-1α and activate HIF-1 target genes to promote aerobic glycolysis in cancer.

PKA pathway: cAMP/PKA signaling influences PGK1 expression and glycolytic activity in response to various stimuli like hormone levels.

PGK1 Related Diseases

Cancer: PGK1 is frequently upregulated in cancers to meet their increased metabolic demands. Its inhibition may combat tumor growth.

Hemolytic anemia: Defects in PGK1 can cause chronic hemolytic anemia due to impaired ATP generation in erythrocytes.

Neurological disorders: Mutations in PGK1 have been linked to such conditions as generalized dystonia and cerebellar ataxia.

Diabetes: Altered PGK1 expression and activity may contribute to pathogenesis of diabetes through disrupted glucose metabolism.

Coronary artery disease: Higher PGK1 levels are observed in coronary artery disease patients, indicating roles in cardiovascular disease.

Skeletal muscle disorders: Mutations impairing PGK1 glycolytic function cause myopathy characterized by muscle weakness.

Biomedical Application of PGK1 Protein

•  Disease biomarker: PGK1 expression levels could indicate tumor progression, diabetes risk, etc.
•  Drug target: Inhibiting PGK1 may slow cancer growth by blocking glycolysis fueling tumor cells.
•  Gene therapy: Correcting defective PGK1 genes may help treat related genetic disorders.
•  Tissue engineering:Studying PGK1's role in differentiated cell metabolism aids disease modeling.

PGK1 has several biochemical functions, for example, ATP binding,phosphoglycerate kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGK1 itself. We selected most functions PGK1 had, and list some proteins which have the same functions with PGK1. You can find most of the proteins on our site.

PGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGK1.

GAPDH;PIK3C2A;FOXO3;GBAS;Cdk1;PCNA;PRKAG1;YWHAZ;Bles03;NRBF2;ATG101;DDA1;UBA5;Csnk1e;SH3GLB2;PRKAG2;p29991-pro_0000037945;tnpA;pstS