PGD
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Official Full Name
phosphogluconate dehydrogenase -
Overview
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. -
Synonyms
PGD;phosphogluconate dehydrogenase;6-phosphogluconate dehydrogenase, decarboxylating;6PGD
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PGD involved in several pathways and played different roles in them. We selected most pathways PGD participated on our site, such as Pentose phosphate pathway,Glutathione metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | CAT,ENO1,PCCB,PCCA,PFKL,ENO3,PRPS1B,ALDOAB,ESD,MTHFR |
| Metabolic pathways | GAD1,PRPS2,PLCD4,AKR1B1L,POLR3H,PLCD3A,PTGDSB,GCSHB,HYKK.2,NME2B.1 |
| Glutathione metabolism | ANPEP,GSTM4,GSTA1,MGST3,GSTO2,GCLM,GPX1A,GGT1,TXNDC12,RRM2 |
| Pentose phosphate pathway | PRPS1,deoC,PGM1,GPIB,RGN,PFKMA,PFKP,FBP1A,FBP1,ALDOAB |
Protein Function
PGD has several biochemical functions, for example, NADP binding,phosphogluconate dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGD itself. We selected most functions PGD had, and list some proteins which have the same functions with PGD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP binding | NOS2,FMO3,MTRR,NOX5,ASPDH,NOS3,G6PD,H6PD,NDOR1,FMO5 |
| phosphogluconate dehydrogenase (decarboxylating) activity | HIBADHB,HIBADH,GLYR1,HIBADHA |
Interacting Protein
PGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGD here. Most of them are supplied by our site. Hope this information will be useful for your research of PGD.
HLA-B;ARF6;IKBKE;USPL1;PRKAB1;TRAF6;LSM8;CDK4;TERF1;GBE1;ssrna_ug;MYC;Magoh;IQCB1;RBM8A
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References
- Hodgson, SH; Juma, E; et al. Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection. FRONTIERS IN MICROBIOLOGY 5:-(2014).
- Ius, F; Sommer, W; et al. Early donor-specific antibodies in lung transplantation: Risk factors and impact on survival. JOURNAL OF HEART AND LUNG TRANSPLANTATION 33:1255-1263(2014).
