PDZK1
-
Official Full Name
PDZ domain containing 1 -
Overview
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. -
Synonyms
PDZK1;PDZ domain containing 1;Na(+)/H(+) exchange regulatory cofactor NHE-RF3;NHERF3;PDZD1;naPi-Cap1;PDZ-containing kidney protein 1;CFTR-associated protein of 70 kDa;sodium-hydrogen exchanger regulatory factor 3;na/Pi cotransporter C-terminal-as
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PDZK1 involved in several pathways and played different roles in them. We selected most pathways PDZK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDZK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDZK1 has several biochemical functions, for example, PDZ domain binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDZK1 itself. We selected most functions PDZK1 had, and list some proteins which have the same functions with PDZK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | ABI1,WRN,UGT1A6B,SLC25A3,GNB1,CDKN1B,STK11,MAPK8IP2,IST1,SREBF1 |
| protein binding | SERP2,BOP1,PTI,FAM40A,LEPROT,COX4I2,TMCO6,MME,RNASE1,MYLK |
| PDZ domain binding | CXADR,SNTA1,EXOC4,NKD1,LIN7C,LRP2,ARHGAP29,PLEKHA2,CFTR,Fzd4 |
| transporter activity | SLC23A2,SYP,SLC2A9L1,CLVS2,FABP4,APODB,NUP155,SLC13A5A,SLC25A38A,ATP5O |
Interacting Protein
PDZK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDZK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDZK1.
CFTR;BCR;GUCY2C;CLCN3;GFAP;PEX5;rep;ruvC;sucB;cirA1;tdh
Resources
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References
- Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).
- O'Leary, PC; Penny, SA; et al. Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer. BMC CANCER 13:-(2013).
