PDK3

  • Official Full Name

    pyruvate dehydrogenase kinase, isozyme 3

  • Overview

    The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the;overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the;tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose;metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and;phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate;dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is;predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding;different isoforms have been found for this gene.

  • Synonyms

    PDK3;pyruvate dehydrogenase kinase, isozyme 3;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial;mitochondrial;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;PDK3_HUMAN;Pyruvate dehydrogenase kinase isoform 3;Pyruvate dehydrogenase kinase isozyme 3;Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial;pyruvate dehydrogenase kinase, isoenzyme 3

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • His
  • GST
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PDK3-2713H Recombinant Human PDK3 protein, His-tagged E.coli Human His 129-369 aa
PDK3-1072H Active Recombinant Human PDK3, GST-tagged Sf9 Cells Human GST Full Length
PDK3-1072 Recombinant Human PDK3 protein, GST-tagged Insect Cells Human GST Full Length
PDK3-1406C Recombinant Chicken PDK3 Mammalian Cells Chicken His
PDK3-652H Recombinant Human PDK3, His-tagged E.coli Human His
Pdk3-8051M Recombinant Mouse Pdk3 protein, His-tagged E.coli Mouse His Gly138~Pro396
PDK3-3328HCL Recombinant Human PDK3 293 Cell Lysate HEK293 Human Non
PDK3-2876HF Active Recombinant Full Length Human PDK3 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-406
Pdk3-4732M Recombinant Mouse Pdk3 protein, His-tagged E.coli Mouse His 131-362aa
Pdk3-4768M Recombinant Mouse Pdk3 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
PDK3-5576H Recombinant Human PDK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK

    Involved Pathway

    PDK3 involved in several pathways and played different roles in them. We selected most pathways PDK3 participated on our site, such as Metabolism,Pyruvate metabolism,Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction ARHGAP26,RDH14A,TAX1BP3,PMCH,ZNRF3,FST,OR52B4,SOX7,ADAM12,SST
    The citric acid (TCA) cycle and respiratory electron transport SLC25A27,PDP1,PDK4,ETFB,SLC25A14,UCP2,FAM36A,UCP3,TACO1,NDUFAF3
    Pyruvate metabolism and Citric Acid (TCA) cycle PDK2B,SLC16A8,MPC1,PDK3B,BRP44,PDP1,D2HGDH,PDK2,PDP2,SLC16A1
    Metabolism CYP2K16,SLC6A7,CA5B,C20orf7,HS3ST4,MED7,AKR1C6,PLCD3,SLC25A11,ATP5L
    Regulation of pyruvate dehydrogenase (PDH) complex PDK2,PDK2B,PDPR,PDP1,PDK3B,PDP2,PDK4
    Pyruvate metabolism LDHB,PKM,DLAT,MDH1,LDHA,SLC16A8,ACOT12,PCK1,PKMA,PDK3B
    Signaling by Retinoic Acid CRABP1A,RDH7,CRABP2B,PDK2B,ALDH8A1,RARG,CRABP2A,AKR1C6,FABP11B,RDH13

    Protein Function

    PDK3 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK3 itself. We selected most functions PDK3 had, and list some proteins which have the same functions with PDK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding AK7,CHD1,CCT6B,HSPD1,ATAD2,FAM20C,MAP2K2,AXL,TSSK2,BMPR1AA
    protein serine/threonine kinase activity PRKACBB,LATS1,RAF1B,MARK1,ULK2,MYLK4,ROCK1,SMOK3B,PSKH2,PDPK1
    protein binding NR1H2,BSX,GNS,MTSS1,CCDC112,ALS2,ICAM5,TNNI3K,ATG7,SORCS1
    protein kinase activity PRKG2,TRIO,TAOK1,MAPK12B,GC2,MMD2,MAPKAPK2A,TGFBR1,RPS6KAL,TEX14
    pyruvate dehydrogenase (acetyl-transferring) kinase activity PDK2,PDK4,PDK1

    Interacting Protein

    PDK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK3.

    EGFR;linkable vandetanib analogue;ECD;TCP1;CCT6A;UTRN;CCT5;CCT3;CCT8;CCT4;VCP;CCT2;ICT1;HLTF;ACAP2;PDK1;CLPP;UBR7;CCT7

    Resources

    Research Area

    Glycolysis

    References

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