PCMT1
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Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase -
Overview
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimers disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
PCMT1;protein-L-isoaspartate (D-aspartate) O-methyltransferase;protein-L-isoaspartate(D-aspartate) O-methyltransferase;L isoaspartyl protein carboxyl methyltransferase;L isoaspartyl/D aspartyl methyltransferase;PCMT 1;PIMT;Protein beta aspartate methyltransferase;Protein L isoaspartate (D aspartate) O methyltransferase;Protein L isoaspartyl/D aspartyl methyltransferase;OTTHUMP00000017397;OTTHUMP00000017398;OTTHUMP00000017400;protein-beta-aspartate methyltransferase;L-isoaspartyl protein carboxyl methyltransferase;protein L-isoaspartyl/D-aspartyl methyltransferase
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Insect Cell
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- Non
- His
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PCMT1 involved in several pathways and played different roles in them. We selected most pathways PCMT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PCMT1 has several biochemical functions, for example, protein binding,protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCMT1 itself. We selected most functions PCMT1 had, and list some proteins which have the same functions with PCMT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STAC,SLC1A1,DMD,TREML1,FAM111A,TSPAN15,ZNF614,CTH,PRDM5,LOXL3 |
| protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | PCMTL,PCMTD2,PCMTD1,PCMT |
Interacting Protein
PCMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCMT1.
RPIA;GABARAPL2;AIMP2;DEGS1;RIPK2;EIF1B;EPB41;TIMP2;Pcmt1;MCC;CD40;HLA-B;VHL;PAK2
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