PCDHGA8
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Official Full Name
protocadherin gamma subfamily A, 8 -
Overview
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. -
Synonyms
PCDHGA8;protocadherin gamma subfamily A, 8;protocadherin gamma-A8;KIAA0327;PCDH GAMMA A8;Protocadherin gamma A8;OTTHUMP00000225708;PCDH-GAMMA-A8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHGA8-1305HCL | Recombinant Human PCDHGA8 cell lysate | Human | Non |
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| PCDHGA8-2561H | Recombinant Human PCDHGA8 Protein, His-tagged | E.coli | Human | His | Gln30-Glu253 |
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Involved Pathway
PCDHGA8 involved in several pathways and played different roles in them. We selected most pathways PCDHGA8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHGA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHGA8 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHGA8 itself. We selected most functions PCDHGA8 had, and list some proteins which have the same functions with PCDHGA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | LETM1,S100Z,PRF1,PCDHB1,PCDH19,PCDHGA2,PRRG2,CDHR1A,CALN1,NUCB2A |
Interacting Protein
PCDHGA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHGA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHGA8.
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