PARK2
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Official Full Name
parkinson protein 2, E3 ubiquitin protein ligase (parkin) -
Overview
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. -
Synonyms
PARK2;PDJ;PRKN;AR-JP;LPRS2;parkin;parkinson protein 2, E3 ubiquitin protein ligase (parkin);E3 ubiquitin-protein ligase parkin;parkin 2;OTTHUMP00000017562;OTTHUMP00000017563;OTTHUMP00000017564;OTTHUMP00000017565;OTTHUMP00000017566;OTTHUMP00000017567;E3 ubiquitin ligase;parkinson disease protein 2;parkinson juvenile disease protein 2;Parkinson disease (autosomal recessive, juvenile) 2, parkin;EC 6.3.2.-
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Cynomolgus
- E.coli
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- His&Myc
Involved Pathway
PARK2 involved in several pathways and played different roles in them. We selected most pathways PARK2 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | SEPT5,SDHC,NDUFB3,PARK7,NDUFB7,NDUFA12,SDHB,SLC6A3,NDUFV3,NDUFB6 |
| Ubiquitin mediated proteolysis | ANAPC4,NEDD4L,TRIP12,PIAS2,SKP2,UBE2NB,UBE1Y1,MID1,AIRE,SIAH1 |
| Protein processing in endoplasmic reticulum | UBQLN4,PLAA,DNAJC3,SSR2,MAPK10,RBX1,MAPK8,SSR4,HSPA6,GSBP9 |
Protein Function
PARK2 has several biochemical functions, for example, F-box domain binding,G-protein coupled receptor binding,Hsp70 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK2 itself. We selected most functions PARK2 had, and list some proteins which have the same functions with PARK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tubulin binding | STMN3,STMN1B,RABGAP1,STMN1A,STMN2B,NCALD,STMN4L,IFT81,AGBL1,ALDOA |
| actin binding | MTSS1LA,SYNE1,EPS8L2,GMFG,ACTR2A,BCL7B,MYBPC2,PLEC,CORO2B,TLN2A |
| SH3 domain binding | CABYR,CRB3,SH3BP1,RAD9A,ABL1,ABI2,INPP5D,CBL,SH3BGR,DNM2 |
| kinase binding | CHIA,MOB4,PFKM,HPCA,CDC6,SLC2A1,WWC2,BTG1,DLG4,PER1 |
| ubiquitin protein ligase activity | MARCH8,UHRF2,RNF6,UBE2NA,NHLRC1,ANAPC11,UBE2NB,AKTIP,UBE2J1,UBE2B |
| protein kinase binding | EMP2,PRC1,CD24,SLC12A5,MAPK6,TRAF2,RCC2,RFFL,ACVRL1,FGFR1OP |
| beta-catenin binding | PTPRU,PXN,CDH24,KLF4,TCF7L2,GRIP1,CBY1,PTBP3,APC2,CHD8 |
| ubiquitin binding | TOP2A,SPRTN,BCL10,RBCK1,UBR5,NBR1,BRAP,FAM125A,FAF2,HSPB1 |
| histone deacetylase binding | PKN1,HEY2,GCM1,D7ERTD443E,HIC1,GMNN,MEF2B,RELA,ZFP932,ZNHIT1 |
Interacting Protein
PARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK2.
PINK1;RANBP2
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