PANK1
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Official Full Name
pantothenate kinase 1 -
Overview
coaA (pantothenate kinase) belongs to the prokaryotic pantothenate kinase family. Pantothenate kinase (PanK; CoaA) is the first enzyme in the Coenzyme A biosynthetic pathway. It phophorylates pantothenate (vitamin B5) to form 4'-phosphopantothenate. Regulation of pantothenate kinase activity by feedback inhibition is the critical factor controlling the intracellular CoA concentration. -
Synonyms
PANK1;EC 2.7.1.33 protein;hPanK protein;hPanK1 protein;MGC24596 protein;PANK protein;PANK1a protein;PANK1b protein;pantothenate kinase 1 protein;pantothenate kinase protein;Pantothenic acid kinase 1 protein
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Myc&DDK
- His&T7
- Non
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PANK1-1520H | Recombinant Human PANK1, GST-tagged | E.coli | Human | GST | C-term-137aa | |
| PANK1-12333M | Recombinant Mouse PANK1 Protein | Mammalian Cell | Mouse | His |
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| PANK1-32H | Recombinant Human PANK1, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PANK1-33H | Recombinant Human PANK1 Protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 373 a.a. |
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| PANK1-34H | Recombinant Human PANK1 Protein, GST-tagged | Wheat Germ | Human | GST | 310 a.a. - 409 a.a. |
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| Pank1-8019M | Recombinant Mouse Pank1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Glu298~Arg500 |
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| PANK1-1278HCL | Recombinant Human PANK1 cell lysate | Human | Non |
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| PANK1-1541HF | Recombinant Full Length Human PANK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 373 amino acids |
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| PANK1-1895H | Recombinant Human PANK1 Protein, His&GST-tagged | E.coli | Human | His&GST | Pro234-Lys593 |
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| PANK1-3402H | Recombinant Human PANK1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Pank1-4668M | Recombinant Mouse Pank1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PANK1-6484M | Recombinant Mouse PANK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PANK1-6484M-B | Recombinant Mouse PANK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PANK1 involved in several pathways and played different roles in them. We selected most pathways PANK1 participated on our site, such as Pantothenate and CoA biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pantothenate and CoA biosynthesis | PANK2,ENPP1,BCAT2,PANK3,AASDHPPT,COASY,VNN1,PPCDC,PANK4,PANK1B |
| Metabolic pathways | PIK3C2G,ETNK2,MGAT4A,UGDH,CYP26B1,CMPK2,CYP2U1,HEXA,ATP6V1G1,MTMR7 |
Protein Function
PANK1 has several biochemical functions, for example, ATP binding,pantothenate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PANK1 itself. We selected most functions PANK1 had, and list some proteins which have the same functions with PANK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SMYHC2,ABCA8,FYN,MAPK12A,RAF1A,NTRK3,NIM1K,NEK4,JAK3,TBK1 |
| pantothenate kinase activity | PANK2,PANK4,PANK3,PANK1B |
Interacting Protein
PANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PANK1.
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References
- Deperas-Kaminska, M; Bajinskis, A; et al. RADIATION-INDUCED CHANGES IN LEVELS OF SELECTED PROTEINS IN PERIPHERAL BLOOD SERUM OF BREAST CANCER PATIENTS AS A POTENTIAL TRIAGE BIODOSIMETER FOR LARGE-SCALE RADIOLOGICAL EMERGENCIES. HEALTH PHYSICS 107:555-563(2014).
- de Villiers, M; Barnard, L; et al. Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis. FEBS JOURNAL 281:4731-4753(2014).
