PAK1
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Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 1 -
Overview
Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms of serine/threonine kinases. These three isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. -
Synonyms
PAK1;p21 protein (Cdc42/Rac)-activated kinase 1;p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) , p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related);serine/threonine-protein kinase PAK 1;STE20 homolog;yeast;p65-PAK;alpha-PAK;STE20 homolog, yeast;p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related);p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast);PAKalpha;MGC130000;MGC130001
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- Insect (sf21)
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
PAK1 involved in several pathways and played different roles in them. We selected most pathways PAK1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| T cell receptor signaling pathway | PPP3CC,CD28,MUC1,GSK3B,MAPK3,CD8A,IKBKB,NFKBIA,MAP3K14,MAP2K7 |
| Natural killer cell mediated cytotoxicity | NCR2,H60a,KIR3DL1,KLRC3,ICAM1,KIR2DS5,FCGR3A,NRAS,PRKCB,VAV2 |
| Ras signaling pathway | PLA2G3,HGF,PRKACA,RALBP1,GNGT2,KITLG,RASAL3,NF1,MAP2K1,PGF |
| Axon guidance | PTK2,GSK3B,SEMA7A,LRRC4C,ACTR3,CSF2,COL9A1B,EPHB3A,L1CAM,IL17RD |
| ErbB signaling pathway | PLCG2,PIK3R3,ABL1,CDKN1BB,PRKCA,CAMK2B1,MAP2K4,MAP2K1,GRB2A,MAPK8 |
| Epithelial cell signaling in Helicobacter pylori infection | RAC1,NFKBIA,TJP1,ATP6V1H,ATP6V0A1,PTPN11,ATP6V1G3,JAM2,MAPK11,PLCG2 |
| Focal adhesion | ACTN3,ITGA4,ITGA6,RAC1A,PAK6,LAMA5,EGFRA,ACTB2,CAV3,COL6A5 |
| Proteoglycans in cancer | WNT9A,FLNC,PPP1R12C,FGF2,PXN,WNT2B,PPP1CA,FZD5,TWIST1,WNT8B |
| Renal cell carcinoma | NRAS,EGLN2,MAPK1,ETS1,SOS1,RBX1,EP300,MAP2K2,RAP1A,HIF1A |
Protein Function
PAK1 has several biochemical functions, for example, ATP binding,Rac GTPase binding,collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK1 itself. We selected most functions PAK1 had, and list some proteins which have the same functions with PAK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | ARHGAP4A,NOXA1,MAP3K11,ARFIP2,PAK2A,SRGAP2,SRGAP2A,PAK4,SRGAP1,CAV1 |
| protein serine/threonine kinase activity | PAK3,HIPK4,AKT1,RPS6KA3B,PLK3,EIF2AK2,PRKCD,MAST2,PRKCQ,PASK |
| contributes_to protein binding | TAF10,MLH1,POLR2A,CRY1A,MEF2A,CPSF3L,MSH2,INTS10,ACVR2A,INHA |
| protein binding | GABPB1,PVRL1,OPRL1,EIF1AX,NUDT21,KRTAP3-3,LSM4,TMEM66,PACSIN3,MAGEA9 |
| ATP binding | KIF22,GCLC,ABCG3,TSSK2,ABCB7,TAF1,CAMKV,SHPRH,RIPK4,MYH3 |
| collagen binding | Pdgfa&Pdgfb,ANTXR1,ABI3BP,LRRC15,DDR2,C1QTNF1,PODN,DCN,HSD17B12,CHADL |
| protein kinase activity | EK1,MAP3K14,MAP3K4,MOK,MAP3K10,HIPK3B,AVP,LMTK2,KDRL,DCLK2 |
Interacting Protein
PAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK1.
RAC1
PAK1 Related Signal Pathway
Resources
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References
- Butz, M; Kast, P; et al. Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. JOURNAL OF STRUCTURAL BIOLOGY 185:168-177(2014).
- Gallicchio, MA; Bach, LA; et al. Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833:2922-2932(2013).
