OAS2

  • Official Full Name

    2-5-oligoadenylate synthetase 2, 69/71kDa

  • Overview

    This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    OAS2;2-5-oligoadenylate synthetase 2, 69/71kDa;2 5 oligoadenylate synthetase 2 (69 71 kD);2-5-oligoadenylate synthase 2;(2-5)oligo(A) synthetase 2;2-5-oligoadenylate synthetase 2;2-5A synthetase 2;MGC78578;p69 OAS / p71 OAS;p69OAS / p71OAS;2-5A synthase 2

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Pig
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
OAS2-309H Recombinant Human OAS2 Protein, His-tagged E.coli Human His Val11~His346
OAS2-11042M Recombinant Mouse OAS2 Protein Mammalian Cell Mouse His
OAS2-4144R Recombinant Rat OAS2 Protein Mammalian Cell Rat His
OAS2-3614HCL Recombinant Human OAS2 293 Cell Lysate HEK293 Human Non
OAS2-1161P Recombinant Pig OAS2 Protein, His-tagged E.coli Pig His Gln21-Gln436
OAS2-3806R Recombinant Rat OAS2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
OAS2-3806R-B Recombinant Rat OAS2 Protein Pre-coupled Magnetic Beads HEK293 Rat
OAS2-4755H Recombinant Human OAS2 Protein (Val11-His346), His tagged E.coli Human His Val11-His346
OAS2-6295M Recombinant Mouse OAS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
OAS2-6295M-B Recombinant Mouse OAS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    OAS2 involved in several pathways and played different roles in them. We selected most pathways OAS2 participated on our site, such as Hepatitis C,Measles,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection NFKBIA,POLR2A,IFIT1,PVRL2,HLA-DQA1,IL6,SP100,CUL1B,TRAF5,NFKBIAA
    Influenza A H2-AB1,EIF2AK2,MAPK10,DNAJB1,SOCS3,VDAC1,NXT2,IFNA2,TLR4,TBK1
    Hepatitis C PIK3CA,OAS1A,CLDN7,EIF2AK2,CLDN5,MAPK8,PPP2R1A,NRAS,BAD,AKT1
    Measles IRAK4,STAT1,IFNGR1,TYK2,CCND3,IFNAR1,CD3D,TRP53,IL1A,IFNGR2

    Protein Function

    OAS2 has several biochemical functions, for example, 2-5-oligoadenylate synthetase activity,ATP binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAS2 itself. We selected most functions OAS2 had, and list some proteins which have the same functions with OAS2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CDH24,DNAJC21,PM20D1.2,ACVRL1,ZBTB25,UNK,UBE3A,ZFP146,ABLIM1A,JAZF1
    zinc ion binding PHF14,ZCCHC13,GCH2,POLR3K,KDM1B,ENPP2,MLL1,ADH4,ZNF331,RNF141
    double-stranded RNA binding IFIH1,TARBP2,TUBB4B,ZFP346,LRRFIP1,HMGB1,SUPV3L1,STAU1,TUBA1B,EIF2AK2
    ATP binding GUK1,TGFBR1A,ROR1,ERCC3,ATP13A1,VMHC,ACSS1,CHD9,SUCLA2,PKM
    2-5-oligoadenylate synthetase activity OASL2,OAS1A,OAS1,OAS3
    protein binding SUPT4H1,TRIM67,CDC45,SOX1,C1QB,FRA10AC1,BRD9,VDAC2,ZBTB26,PRKCD

    Interacting Protein

    OAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAS2.

    CLK3

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    Cytokines

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