Ntrk3
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Official Full Name
neurotrophic tyrosine kinase, receptor, type 3 -
Overview
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates p -
Synonyms
NTRK3;neurotrophic tyrosine kinase, receptor, type 3;NT-3 growth factor receptor;TRKC;GP145-TrkC;ETV6-NTRK3 fusion;tyrosine kinase receptor C;ETS related protein-neurotrophic receptor tyrosine kinase fusion protein;gp145(trkC);AW125844;Ntrk3_tv3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Chicken
- Sus scrofa (Pig)
- HEK293
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Mammalian cells
- Insect Cell
- Mouse
- Human Cell
- Insect Cells
- Insect cells
- HEK293T
- E.coli expression system
- His
- GST
- His&Fc
- Fc
- C-His&hFc
- Non
- His&Flag
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Ntrk3 involved in several pathways and played different roles in them. We selected most pathways Ntrk3 participated on our site, such as Neurotrophin signaling pathway,Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ntrk3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | ARHGDIG,PRKCD,MAP2K7,MAPK13,NFKBIA,MAGED1,RAP1A,RPS6KA5,IRAK1,SOS1 |
| Central carbon metabolism in cancer | HKDC1,SLC16A3,PIK3CB,HIF1A,SLC2A2,PDGFRA,KIT,PKM2,PIK3R5,AKT2 |
Protein Function
Ntrk3 has several biochemical functions, for example, ATP binding,ephrin receptor binding,neurotrophin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ntrk3 itself. We selected most functions Ntrk3 had, and list some proteins which have the same functions with Ntrk3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| p53 binding | TP53,SMARCB1,ZNF385D,BANP,PLK3,ZMAT3,ZNF385A,HTT,SMYD2,EP300 |
| neurotrophin receptor activity | NTRK2B |
| ephrin receptor binding | Anks1,SIPA1L1,CBL,EFNA3B,EFNB3,SRC,EFNB2,EFNA2A,EFNA5,CDK5 |
| protein binding | TTC8,ATP6V1F,LAMTOR1,HSP90AA1.1,TTBK2,CTPS2,VSNL1,IGF2BP1,SCN5A,WWC1 |
| ATP binding | EIF2AK4,PIP5K1B,RIPK2,PFAS,CDK11B,ACVR1BA,DYRK3,HIPK2,KIF27,BMPR1BB |
| transmembrane receptor protein tyrosine kinase activity | FGFR1B,NTRK2B,TYRO3,KITB,ERBB3B,EPHA2A,EGFRA,EK1,INSRB,EGFR |
| neurotrophin binding | NGFR,NTRK2,NTRK1 |
Interacting Protein
Ntrk3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ntrk3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ntrk3.
SORT1;saicar;PKM;PTPN1;abl-tide;HSP90AB1;IRAK3
Resources
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References
- Takahashi, H; Arstikaitis, P; et al. Postsynaptic TrkC and Presynaptic PTP sigma Function as a Bidirectional Excitatory Synaptic Organizing Complex. NEURON 69:287-303(2011).
- Manda, SS; Nirujogi, RS; et al. Identification and Characterization of Proteins Encoded by Chromosome 12 as Part of Chromosome-centric Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 13:3166-3177(2014).
